Effects of interferon-gamma therapy on thyroid function, T-lymphocyte subpopulations and induction of autoantibodies

The Journal of Clinical Endocrinology and Metabolism
A W KungC L Lai

Abstract

Treatment with human leucocyte interferon (IFN alpha) has been associated with the development of thyroid autoimmunity and hypothyroidism, but it is not certain whether this phenomenon was a result of contamination with IFN gamma, which induced HLA class II antigen expression on T-lymphocytes. We prospectively studied 11 subjects (5 females and 6 males; mean age, 26.8 yr; range, 18-36) with chronic active hepatitis B who were randomized to receive recombinant human IFN gamma (rhIFN gamma; 10(6) U/m2.day, im, 3 times/week) for 16 weeks. Goiter was not present, and no patient had a history or family history of autoimmune diseases. Serial thyroid functions, including serum T4, T3, free thyroid hormone index, free T4 and TSH before, during, and on subsequent follow-up for a period of 1 yr were all normal. Eight patients had adequate serial samples for study of serological and lymphocyte subpopulations. None of the patients treated with rhIFN gamma developed thyroglobulin or thyroid microsomal antibodies. However, four patients developed antinuclear and smooth muscle autoantibodies during or after rhIFN gamma treatment. Treatment with rhIFN gamma resulted in a significant increase in circulating T-lymphocytes and HLA-DR-positive T-c...Continue Reading

Citations

Jul 21, 2000·Arthritis and Rheumatism·Y Ioannou, D A Isenberg
Mar 10, 1995·Life Sciences·S H YoshidaM E Gershwin
Aug 31, 1991·Lancet·K HoekmanH M Pinedo
Dec 20, 1995·Toxicology·T Vial, J Descotes
Oct 1, 1994·Baillière's Clinical Endocrinology and Metabolism·M Lambert
Jun 20, 2002·Clinical Endocrinology·Vincent WongN Wah Cheung
Dec 21, 1995·The New England Journal of Medicine·M I Surks, R Sievert
Jul 16, 2011·International Journal of Biomedical Imaging·Maria Lyra, Agapi Ploussi
Apr 1, 1992·Clinical Endocrinology·A P Weetman
Jan 18, 2014·Endocrine Reviews·Bernadette Biondi, Leonard Wartofsky
Jan 1, 1992·International Reviews of Immunology·G KroemerC Martínez
May 15, 1997·Medizinische Klinik·J FritzschH J Heberling
Feb 2, 2021·Frontiers in Immunology·Maria A Bacalao, Anne B Satterthwaite
Dec 1, 1991·Baillière's Clinical Endocrinology and Metabolism·J E DumontP P Roger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Thyroiditis

Autoimmune thyroiditis is an inflammatory disease of thyroid gland due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-cells and thyroid autoantibodies. Discover the latest research on autoimmune thyroiditis here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
P CaturegliN R Rose
Thyroid : Official Journal of the American Thyroid Association
Mark F Prummel, Peter Laurberg
© 2021 Meta ULC. All rights reserved