Effects of interferon treatment on liver histology and allograft rejection in patients with recurrent hepatitis C following liver transplantation

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
R Todd StravitzRobert A Fisher

Abstract

Recurrent hepatitis C after liver transplantation remains a significant cause of graft loss and retransplantation. Although treatment of recurrent hepatitis C with interferon-based regimens has become widely accepted as safe and can lead to sustained virologic clearance of hepatitis C virus (HCV) RNA, long-term histologic improvement and the risk of precipitating graft rejection remain controversial. The present study is a retrospective evaluation of the clinical and histological consequences of treating recurrent hepatitis C with interferon-based therapy in a selected group of liver transplant recipients. Twenty-three liver transplant recipients with recurrent hepatitis C and histologic evidence of progressive fibrosis completed at least 6 months of interferon, 83% of whom received pegylated-interferon alpha-2b; only 4 tolerated ribavirin. Overall, 11 patients (48%) had undetectable HCV RNA at the end of 6 months of treatment. Of these patients, 3 remained HCV RNA-negative on maintenance interferon monotherapy for 33 months, and the other 8 (35%) completed treatment and remained HCV RNA-undetectable 24 weeks after discontinuation of interferon. Overall necroinflammatory activity in liver biopsies obtained 2 years after HCV RNA...Continue Reading

References

Jun 1, 1991·The Journal of Clinical Investigation·W HeagyR W Finberg
Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Oct 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C FérayH Bismuth
Oct 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T L WrightM Urdea
Nov 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C FérayH Bismuth
Mar 28, 1996·The New England Journal of Medicine·E J GaneR Williams
Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K H BökerM P Manns
Mar 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Aug 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T BizollonC Trepo
May 15, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·E J GaneR Williams
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P A SheinerC M Miller
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
Mar 13, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·D V GopalH R Rosen
Apr 17, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S G Hübscher
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J AhmadA O Shakil
Oct 27, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A B AlbertiG Pinzello
Jun 29, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kozhikode V Narayanan MenonMichael Charlton
Apr 12, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gary L DavisDaniel M Rosenberg
May 30, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mylène SebaghMichel Reynès

❮ Previous
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Citations

Oct 3, 2006·Journal of Hepato-biliary-pancreatic Surgery·Shigeru MarubashiMorito Monden
Apr 9, 2008·Journal of Hepato-biliary-pancreatic Surgery·Sumihito Tamura, Yasuhiko Sugawara
Apr 12, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Robert G GishK Rajender Reddy
Aug 19, 2005·Nature·Robert S Brown
Feb 9, 2005·Transplantation·Christos TriantosAndrew Burroughs
Jun 27, 2008·Transplantation·George Mells, James Neuberger
Apr 21, 2007·Journal of Gastroenterology and Hepatology·UNKNOWN Asian Pacific Association for the Study of the Liver (APASL) Hepatitis C Working PartyR Tateishi
Apr 22, 2005·Dermatologic Therapy·Bradley T Kovach, Thomas Stasko
Nov 13, 2008·Paediatric Drugs·Suzanne M Davison, Deirdre A Kelly
Jul 24, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Valentina Rosa BertuzzoAntonio Daniele Pinna
Oct 29, 2011·Clinics in Liver Disease·Alpna R Limaye, Roberto J Firpi
Jul 16, 2008·Clinics in Liver Disease·Elizabeth C Verna, Robert S Brown
May 13, 2008·Gastroenterology·Sandeep Mukherjee, Michael F Sorrell
Jul 4, 2007·Clinics in Liver Disease·Marina Berenguer
Mar 11, 2006·Infectious Disease Clinics of North America·Scott W Biggins, Norah A Terrault
Jan 16, 2007·Journal of Hepatology·Alexander Kuo, Norah A Terrault
Sep 15, 2006·Clinics in Liver Disease·Sakib K Khalid, Jeffrey S Crippin
Dec 14, 2006·Clinics in Liver Disease·Elizabeth C Verna, Robert S Brown
Mar 5, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Andrej PotthoffMatthias J Bahr
Jun 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K WattM Charlton
Jan 16, 2009·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S DingesUNKNOWN Swiss Association for the Study of the Liver (SASL 17)
Nov 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Bruno RocheDidier Samuel
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Fredric D GordonHugo E Vargas
Aug 17, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Arno KornbergUtz Settmacher
Mar 16, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Rosângela TeixeiraThomas D Schiano
Jun 27, 2007·Alimentary Pharmacology & Therapeutics·R R ArjalH R Rosen
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M SchmedingP Neuhaus
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T WalterO Boillot
Oct 1, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexander KuoNorah A Terrault
Dec 19, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T BizollonC Trepo
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marc G GhanyUNKNOWN American Association for the Study of Liver Diseases
May 21, 2008·European Journal of Clinical Investigation·T ReibergerM Peck-Radosavljevic
Apr 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marina BerenguerJoaquín Berenguer
Jul 28, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E OtonM L Mateos
Mar 17, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HeydtmannD Mutimer
Dec 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Thomas WalterJérôme Dumortier
Sep 20, 2007·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Marina Berenguer
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Kuo, N A Terrault
Apr 21, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Natalie BzowejUNKNOWN PHOENIX Study Group
Jul 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Paul J PockrosAnna S Lok
Jan 10, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Marina BerenguerJose Ignacio Herrero
Aug 19, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·John O'Grady
Mar 15, 2005·Journal of Hepatology·Isabelle Morard, Francesco Negro
Oct 7, 2005·Clinics in Liver Disease·Marina Berenguer

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