Jan 1, 1988

Effects of interferons, interferon inducers and growth factors on phagocytosis measured by quantitative determination of synthetic compound ingested by mouse bone marrow-derived macrophages

Archivum Immunologiae Et Therapiae Experimentalis
B Szulc, E Piasecki

Abstract

Sodium salt of 9-oxo-10-acridineacetohydroxamic acid (HCA), a new synthetic compound, forms small crystals in aqueous solution. These crystals were easily phagocytized by the mouse bone marrow-derived macrophages. The ingested HCA crystals were visible under light microscope as dark granules. The degree of phagocytosis was estimated by the spectroscopic measurements of absorption of ingested HCA. About 10 day-old cultures of mouse bone marrow-derived macrophages were found to be suitable for a study on the effect of murine or human interferons. It was observed that murine interferons alpha, beta and gamma at low concentrations (10-200 U/ml) stimulated and higher concentrations (400-1000 U/ml) had no effect on the phagocytosis. Previous treatment of interferons with anti-IFN sera abolished the effect of the interferons. CMA-induced interferon and growth factors were found to modify the phagocytic activity of macrophage cultures.

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Mentioned in this Paper

Crystal - Body Material
Alkalescens-Dispar Group
Epidermal Growth Factor
Murine
Hydroxamic Acids
Human leukocyte interferon
Staphylococcal enterotoxin A
Growth Substances
Phosphoglycerate Dehydrogenase Activity
Interferon

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