Abstract
A Plasmodium falciparum sporozoite vaccine, composed of a synthetic dodecapeptide (NANP)3 coupled to tetanus toxoid (TT), was injected, at weeks 0 and 8, into non-immune volunteers in two randomized double-blind placebo-controlled trials. In the first trial, 37 volunteers received the vaccine simultaneously with placebo (group 1), 0.5 x 10(6-) (group 2), or 1.5 x 10(6) U (group 3) of recombinant human interferon-alpha (= IFN-alpha). In the second trial, 35 other volunteers received the vaccine with placebo (group 4), 0.25 x 10(6) (group 5), or 1.0 x 10(6) IU (group 6) of interferon-gamma (= IFN-gamma). Immunizations were well tolerated and resulted in seroconversion rates (greater than or equal to 4-fold increase of antibody titre in immunofluorescence or enzyme-linked immunosorbent assays) of 67-100% of volunteers. IFN-alpha significantly enhanced the IgG antibody titres in ELISA to malaria peptide.
References
Mar 23, 1978·Nature·T SasazukiS Naito
Jun 30, 1979·Lancet·L H CollierJ Mortimer
Jun 21, 1985·Science·F ZavalaV Nussenzweig
Jul 16, 1987·Nature·D A HerringtonD Gillessen
Oct 8, 1987·The New England Journal of Medicine·C A Dinarello, J W Mier
Apr 1, 1988·European Journal of Immunology·F SinigagliaJ R Pink
Jun 6, 1987·Lancet·W R BallouJ F Young
May 16, 1986·Science·A FerreiraV Nussenzweig
Aug 7, 1987·Science·S L HoffmanM Mugambi
Jul 1, 1987·Molecular and Biochemical Parasitology·H A del PortilloV Enea
Nov 1, 1987·The Journal of Experimental Medicine·F ZavalaV Nussenzweig
Apr 24, 1987·Science·J E EganI Schneider
Aug 10, 1984·Science·J B DameD Roberts
Jan 1, 1984·Journal of Interferon Research·I GresserJ Uriel
Jun 1, 1984·European Journal of Clinical Microbiology·P J GrobM Fernex
Citations
Dec 1, 1992·International Journal for Parasitology·N C Smith
May 1, 1993·Trends in Pharmacological Sciences·F M Audibert, L D Lise
Jun 1, 1993·Immunology Today·F M Audibert, L D Lise
Jan 1, 1991·Parasitology Today·E M RileyM Troye-Blomberg
Mar 15, 2000·Vaccine·V E SchijnsP Staeheli
Jul 31, 1998·Immunology and Cell Biology·J Kovarik, C A Siegrist
Apr 22, 2011·Expert Review of Vaccines·Paola RizzaFilippo Belardelli
Apr 29, 1999·Annals of Medicine·F Dorner, P N Barrett
Dec 3, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kanika KanchanSaman Habib
Jun 2, 2005·Vaccine·Meng YuDavid C Jackson
Jan 1, 1990·International Reviews of Immunology·R Edelman, C O Tacket
Aug 6, 2003·Expert Review of Vaccines·Richard T Kenney, Robert Edelman
May 23, 2003·Genes and Immunity·C AucanA V S Hill
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen K DakappagariPravin T P Kaumaya
Aug 1, 1992·AIDS Research and Human Retroviruses·R Edelman
Oct 1, 1991·Clinical Microbiology Reviews·S E Maddison
Jul 27, 1990·Science·H M EtlingerA Trzeciak