PMID: 8604021Mar 1, 1996Paper

Effects of interleukin-13 on human neutrophil functions

Journal of Leukocyte Biology
D GirardA D Beaulieu

Abstract

It was recently shown that interleukin-13 (IL-13) induces the expression and release of the IL-1 decoy receptor (type II) in human neutrophils along with the production of the IL-1 receptor antagonist. In the present study we focused on further studying the modulatory effects of IL-13 on these cells. We found that recombinant human IL-13 (rhIL-13) induces cellular morphological changes in neutrophils that are typical of activated cells. Furthermore, rhIL-13 was shown to increase tyrosine phosphorylation of several neutrophil proteins. We also demonstrate that this cytokine stimulates de novo RNA synthesis in a concentration-dependent fashion as measured by [5-3H]uridine incorporation and that rhIL-13 induces the synthesis of several neutrophil proteins according to high-resolution two-dimensional gel electrophoresis of metabolically [35S]-labeled cells. We observed that the IL-8 levels in the external milieu of IL-13-stimulated cells was almost fivefold increased when compared with control cells. Finally, we observed that rhIL-13 has no significant effect on phagocytosis and apoptosis. Taken together, our results demonstrate that IL-13 is a modulator of several human neutrophil functions. This leads us to conclude that the modu...Continue Reading

Citations

Dec 29, 1998·Human & Experimental Toxicology·P LabbéD Girard
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S AbdelilahQ Hamid
Jul 20, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Anouk Lavoie-LamoureuxJean-Pierre Lavoie
Jan 23, 1999·International Reviews of Immunology·P Chomarat, J Banchereau
Jan 10, 1998·British Journal of Pharmacology·N J JordanJ Westwick
Nov 5, 2002·Human & Experimental Toxicology·M Pelletier, D Girard
Oct 28, 2020·Antioxidants & Redox Signaling·Christian SchulzHellen Ishikawa-Ankerhold
May 31, 2012·The American Journal of Pathology·Agnieszka Rynda-AppleAllen G Harmsen
Feb 13, 1999·Kidney International·R KettritzH Haller
Mar 21, 2008·Kidney International·M SandoviciL E Deelman
Dec 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M GonçalvesD Girard

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