Effects of interleukin-2 and cyclosporin A on pathologic features in Mycoplasma pneumonia

American Journal of Respiratory and Critical Care Medicine
H TanakaH Tamura

Abstract

To elucidate the immunopathologic mechanisms of Mycoplasma pneumonia, the effects of interleukin-2 (IL-2) and cyclosporin A (CYA) on Mycoplasma pneumonia in mice were investigated. Mice were intranasally inoculated with Mycoplasma pulmonis (M. pul) and treated with IL-2, CYA, or minocycline (MINO) every day between Days 3 and 9. They were killed at Days 7, 14, or 21 after the inoculation. Cell-mediated immunity (CMI) of the host was assessed by delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC). Peribronchial and perivascular lymphocyte cuffing and the accumulation of macrophages at the ends of bronchioles were exacerbated (p < 0.05) in IL-2-treated mice at Day 14 and reduced (p < 0.05) in CYA-treated mice at Day 7. Although the DTH responses to SRBC of saline-inoculated, IL-2-treated mice were increased at Days 7 (p < 0.01) and 14 (p < 0.05), those of M. pul-inoculated, IL-2-treated mice at Day 7 could not recover to the control level. The CMI levels of M. pul-inoculated, CYA-treated mice were decreased at Days 7, 14 (p < 0.05), and 21 (p < 0.01). Mycoplasma organisms in the lung showed the greatest decrease (p < 0.05) in MINO- and IL-2-treated mice, but increased at Day 21 (p < 0.05) in mice treated with IL-2...Continue Reading

Citations

Jul 26, 2003·Seminars in Pediatric Infectious Diseases·Ari BitnunSusan Richardson
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M RadisicP Pardo
Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·M NaritaY Sakiyama
Feb 18, 2017·International Journal of Molecular Sciences·Kyung-Yil Lee
Mar 1, 2012·Korean journal of pediatrics·You-Sook Youn, Kyung-Yil Lee
Jan 27, 2006·Pediatric Pulmonology·Kyung-Yil LeeByung-Churl Lee
Jul 20, 2007·Wiener klinische Wochenschrift·Florian DaxboeckGerold Stanek
Jul 30, 2008·Expert Review of Anti-infective Therapy·Kyung-Yil Lee
Nov 24, 2007·Journal of Medical Microbiology·Naoyuki MiyashitaMikio Oka

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

Scandinavian Journal of Infectious Diseases
Kyung-Yil LeeByung-Churl Lee
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
J M LlibreC Murcia
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
M RadisicP Pardo
© 2021 Meta ULC. All rights reserved