Abstract
To elucidate the immunopathologic mechanisms of Mycoplasma pneumonia, the effects of interleukin-2 (IL-2) and cyclosporin A (CYA) on Mycoplasma pneumonia in mice were investigated. Mice were intranasally inoculated with Mycoplasma pulmonis (M. pul) and treated with IL-2, CYA, or minocycline (MINO) every day between Days 3 and 9. They were killed at Days 7, 14, or 21 after the inoculation. Cell-mediated immunity (CMI) of the host was assessed by delayed-type hypersensitivity (DTH) to sheep red blood cells (SRBC). Peribronchial and perivascular lymphocyte cuffing and the accumulation of macrophages at the ends of bronchioles were exacerbated (p < 0.05) in IL-2-treated mice at Day 14 and reduced (p < 0.05) in CYA-treated mice at Day 7. Although the DTH responses to SRBC of saline-inoculated, IL-2-treated mice were increased at Days 7 (p < 0.01) and 14 (p < 0.05), those of M. pul-inoculated, IL-2-treated mice at Day 7 could not recover to the control level. The CMI levels of M. pul-inoculated, CYA-treated mice were decreased at Days 7, 14 (p < 0.05), and 21 (p < 0.01). Mycoplasma organisms in the lung showed the greatest decrease (p < 0.05) in MINO- and IL-2-treated mice, but increased at Day 21 (p < 0.05) in mice treated with IL-2...Continue Reading
Citations
Jul 26, 2003·Seminars in Pediatric Infectious Diseases·Ari BitnunSusan Richardson
Nov 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M RadisicP Pardo
Aug 31, 2001·Clinical and Diagnostic Laboratory Immunology·M NaritaY Sakiyama
May 15, 2002·Chest·Hiroshi TanakaShosaku Abe
Aug 12, 2009·Pediatric Neurology·Mitsuo Narita
Jun 1, 2016·Frontiers in Microbiology·Hiroshi Tanaka
Feb 18, 2017·International Journal of Molecular Sciences·Kyung-Yil Lee
Mar 1, 2012·Korean journal of pediatrics·You-Sook Youn, Kyung-Yil Lee
Jan 27, 2006·Pediatric Pulmonology·Kyung-Yil LeeByung-Churl Lee
Apr 7, 2015·Infection & chemotherapy·Kyung-Yil Lee
Jul 20, 2007·Wiener klinische Wochenschrift·Florian DaxboeckGerold Stanek
Jul 30, 2008·Expert Review of Anti-infective Therapy·Kyung-Yil Lee
Nov 4, 2000·Clinical and Diagnostic Laboratory Immunology·M NaritaT Togashi
Nov 3, 2017·The Pediatric Infectious Disease Journal·Mi Seon HanEun Hwa Choi
Nov 24, 2007·Journal of Medical Microbiology·Naoyuki MiyashitaMikio Oka
Sep 26, 2017·Internal Medicine·Takeshi SarayaHajime Takizawa