Effects of intermission and resumption of long-term testosterone replacement therapy on body weight and metabolic parameters in hypogonadal in middle-aged and elderly men

Clinical Endocrinology
Aksam YassinLouis Gooren

Abstract

In addition to primary and secondary ('classical') hypogonadism, hypogonadism occurring in middle-aged and elderly men has been recognized. There is evidence that restoring T levels to normal improves body weight, serum lipids and glucose levels. Observational registry study. Two hundred and sixty-two hypogonadal, middle-aged and elderly, men received testosterone replacement treatment (TRT). After having been on TRT for a mean duration of 65·5 months, TRT was temporarily intermitted in 147 patients for a mean of 16·9 months (Group I) due to cost reimbursement issues and in seven men due to prostate cancer. All these men resumed TRT for a mean period of 14·5 months. Of the cohort, 115 men were treated continuously (designated as Group C). To compare on-treatment to off-treatment periods, three periods of equal duration were defined: pre-intermission (on TRT), during intermission (off TRT) and post-intermission (on TRT after resumption of TRT). For proper comparison, the same periods were analysed for those patients who continued TRT throughout (Group C). Variables of body weight, glucose metabolism, lipids, blood pressure and C-reactive protein (CRP). In Group C there was a continuous improvement of body weight, serum lipids, g...Continue Reading

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Citations

Feb 19, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaMikio Namiki
Jan 9, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam YassinGheorge Doros
Mar 2, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Ozan EfesoySelahittin Çayan
Mar 12, 2017·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Aksam YassinDany-Jan Yassin
Apr 24, 2018·Clinical Endocrinology·Mathis Grossmann
Jan 13, 2018·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Alessandra BarassiGian Vico Melzi d'Eril
Jan 8, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·A YassinA Al Ansari
May 13, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Muharrem Bayrak
Jun 9, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Mohammed Elimam Ahamed MohammedMustafa Musa
Mar 16, 2017·The American Journal of Gastroenterology·Monika SarkarNorah Terrault
Jul 31, 2018·Journal of the Endocrine Society·Ferdinand RoelfsemaJohannes D Veldhuis
Jan 18, 2019·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Monica Caliber, Geoff Hackett
Nov 15, 2016·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Kazuyoshi ShigeharaMikio Namiki
May 28, 2020·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Yavor AssyovZdravko Asenov Kamenov
Oct 4, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Monika A SarkarUNKNOWN NASH Clinical Research Network

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