PMID: 9430239Jan 16, 1998Paper

Effects of intermittent administration of low dose human PTH(1-34) on cancellous and cortical bone of lumbar vertebral bodies in adult beagles

Bone
L ZhangM Hori

Abstract

This study assessed the effect of low dose human parathyroid hormone [hPTH(1-34)] administration on cancellous and cortical bone of lumbar vertebrae in intact male beagles. 16 19-20-month-old beagle dogs were randomized into four groups: in group 1, the vehicle control group, saline was injected daily; in group 2, the sequential group, 0.375 microg/kg of PTH was injected daily for 4 weeks, then off 8 weeks, and this sequence was once repeated for another 4 and 8 weeks; in group 3, the same dose of PTH was injected once per week for 24 weeks; and, in group 4, PTH was injected three times per week for 24 weeks. Histomorphometric assessment on cancelllous and cortical bone (both ventral and dorsal shell) and two-dimensional node-strut analysis were done on the fifth lumbar vertebral bodies after calcein double bone labeling. In intact adult beagles, on the group treated with 0.375 microg/kg per day three times per week (group 4): (1) had a higher mean value in cancellous bone formation parameters [osteoid surface (+74%), osteoid volume (twofold), mineral apposition rate (+21%), and bone formation rate (twofold)]; (2) exhibited no effect on cortical thickness and porosity in both the ventral and dorsal shell; and (3) showed a lower...Continue Reading

References

Jul 1, 1989·Bone and Mineral·J E CompstonN J Garrahan

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Citations

May 11, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T HiranoJ M Hock
Jan 10, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D B BurrJ M Hock
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D W DempsterR Lindsay
Nov 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Arata NakajimaMasashi Yamazaki
Mar 15, 2000·Molecular and Cellular Endocrinology·J F Reidhaar-OlsonH E Selick
Oct 14, 2004·American Journal of Veterinary Research·Kristin C BackstromStephen E Weisbrode
Feb 18, 1999·Toxicology Letters·T TanizawaM Hori
Mar 15, 2005·Acta Orthopaedica Scandinavica·Ralf Skripitz, Per Aspenberg
Dec 6, 2005·Clinics in Sports Medicine·Michael C Koester, Kurt P Spindler
Jul 2, 2004·Basic & Clinical Pharmacology & Toxicology·Kim T BrixenBente Lomholt Langdahl
Jun 20, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Paul J KostenuikDavid Lacey
Sep 15, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mohammad ShahnazariNancy E Lane
Mar 28, 2006·Joint, Bone, Spine : Revue Du Rhumatisme·Thierry Thomas
Dec 1, 2001·The Tohoku Journal of Experimental Medicine·T TsuchidaK Sato
Jul 27, 2017·ACS Chemical Neuroscience·Damon C BarbacciAmina S Woods
Jan 5, 2011·The Journal of Bone and Joint Surgery. British Volume·H DaugaardK Soballe

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