Effects of intermittent weight-bearing and clenbuterol on disuse atrophy of rat hindlimb muscles

Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō
T Yamazaki

Abstract

The present study was undertaken to evaluate the effects of intermittent weight-bearing (IWB) combined with β 2-agonist clenbuterol (Cb) medication for suppressing muscle atrophy during progressive disuse atrophy. Male Wistar rats (age: 8weeks, body weight: 232 ± 14 g) were divided into a control group (CON) and an experimental group. The experimental group was further subdivided into a Cb medication group under normal conditions and a hindlimb unweighting (HU) treatment group. The HU treatment group was composed of four groups: HU treatment-only, HU treatment + IWB, HU treatment + Cb medication and HU treatment + IWB + Cb medication. IWB was performed by temporarily removing the suspension device for one hour daily. On Day 14, bilateral soleus muscle (SOL) and extensor digitorum longus muscle (EDL) were extracted. Muscles from the right side were used for the measurement of contractile properties (physiological functional evaluations). Muscles from the left side were used for histochemical and biochemical analysis. During HU, IWB combined with Cb medication worked to preserve the wet weight and relative weight of SOL as compared to CON. Its contractile properties were affected by weight-bearing, while the cross-sectional area ...Continue Reading

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Jan 1, 2001·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·T YamazakiK Tachino
Jan 1, 2003·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki Yamazaki

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Citations

Jan 1, 2009·Journal of the Japanese Physical Therapy Association = Rigaku Ryōhō·Toshiaki YamazakiKatsuhiko Tachino
Nov 15, 2018·Physiological Reviews·Lars LarssonMarco Sandri

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