PMID: 9529170Apr 7, 1998Paper

Effects of intra-abdominal hypertension on hepatic energy metabolism in a rabbit model

The Journal of Trauma
T NakataniK Kobayashi

Abstract

Intra-abdominal hypertension is known to decrease hepatic blood flow, but its effect on hepatic energy level has not described. Fifty-three rabbits were mechanically ventilated and divided into five groups. Intra-abdominal hypertension was induced by saline infusion and maintained for 30 minutes. Hepatic sinusoidal functional blood flow was evaluated by means of indocyanine green disappearance rate (ICG-K), hepatic mitochondrial redox status was evaluated by arterial ketone body ratio, and tissue energy level was evaluated by energy charge (EC). At an intra-abdominal pressure of 20 mm Hg, ICG-K was significantly decreased, with no decrease in EC. At 30 mm Hg, hypoxemia developed and the ICG-K decreased further, with significant decreases observed in arterial ketone body ratio and EC. The latter were not increased by administration of oxygen. At an intra-abdominal pressure of 20 mm Hg, a slight decrease in sinusoidal flow did not affect hepatic energy level. At 30 mm Hg, a reduced hepatic mitochondrial redox status and a decreased energy level were attributed to a decrease in sinusoidal flow in this animal model.

References

Jun 1, 1990·The Australian and New Zealand Journal of Surgery·C Platell, S Levitt
Sep 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·S UnoK Ozawa
Jan 1, 1984·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·T NakataniT Tobe
Nov 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J Groszmann
Jan 1, 1995·The Journal of Trauma·J BendahanR Muller
May 1, 1993·The American Journal of Emergency Medicine·T NakataniK Kobayashi
Jan 1, 1997·Journal of Internal Medicine·H SugermanL Wolfe
Mar 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S T ReevesE D Norcross
May 1, 1997·American Journal of Surgery·B K OelschlagerM H Meissner
Jun 1, 1997·The Journal of Trauma·G L BloomfieldH J Sugerman

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Citations

Oct 24, 2013·Medizinische Klinik, Intensivmedizin und Notfallmedizin·J Reibetanz, C-T Germer
May 9, 2001·Annales de chirurgie·T PottecherA Launoy
Dec 11, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gianni BiancofioreFranco Mosca
Mar 4, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Michael L Cheatham
Jul 20, 2011·Journal of Emergencies, Trauma, and Shock·Theodossis S PapavramidisNicki Papavramidou
May 22, 2013·The Journal of Surgical Research·Laura Correa-MartínFrancisco M Sánchez-Margallo
Dec 7, 2010·Enfermedades infecciosas y microbiología clínica·Enrique Piacentini, Carles Ferrer Pereto
Mar 11, 2005·Current Opinion in Critical Care·Manu L N G MalbrainTom J R De Potter
Jan 5, 2011·Critical Care Medicine·Julia Wendon

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