Effects of intra-amygdalar thyrotropin releasing hormone (TRH) and its antagonism by atropine and benzodiazepines during stress ulcer formation in rats

Pharmacology, Biochemistry, and Behavior
A RayR M Sullivan

Abstract

Bilateral intra-amygdalar (i/am) microinjections of TRH (1 and 10 micrograms) and physostigmine (10 micrograms) into the central nucleus (CEA) aggravated cold restraint stress (3 hr at 4 degrees C) induced gastric ulcer formation in rats, whereas atropine (1, 5 and 10 micrograms) attenuated this phenomenon. Similar stress ulcer reducing effects were seen with chlordiazepoxide (CDP, 10 mg/kg, IP) and midazolam (1, 3 and 10 micrograms, i/am). Pretreatment of rats with atropine or CDP antagonized the ulcerogenic effects of both TRH and physostigmine. Further, when administered intra-CEA, midazolam neutralized the effects of TRH in a dose-related manner. These results are discussed in light of TRH-acetylcholine-benzodiazepine/GABA interactions within the amygdaloid complex during stress ulcer formation.

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Citations

Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·S PuriP Sen
Mar 1, 1996·Pharmacology, Biochemistry, and Behavior·R E Johnston
Sep 1, 1991·Brain Research. Brain Research Reviews·G B GlavinD E Hernandez
May 30, 1994·Behavioural Brain Research·K S QuigleyG G Berntson
Mar 13, 2001·Molecular Psychiatry·M Davis, P J Whalen
Jun 9, 2020·Brain Research·Luciana Taschetto VeyMarilise Escobar Burger

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