Effects of intra-articular hyaluronic acid associated to Chitlac (arty-duo®) in a rat knee osteoarthritis model

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
Francesca SalamannaM Fini

Abstract

Among conventional osteoarthritis (OA) treatments, intra-articular (i.a) viscosupplementation with hyaluronic acid (HA) is used to restore joint viscoelasticity. However, the rapid clearance and elimination of HA may limit its application. The aim of this study was to verify the improved efficacy of HA within the joint, using a lactose-modified chitosan (chitlac) as a potentially chondroprotective additive. Four weeks after induction of experimental OA by destabilization of the medial meniscus (DMM), 12-week-old Sprague Dawley male rats (n = 30), received once a week, for three weeks, i.a injections of: (i) HA associated to chitlac (ARTY-DUO®), (ii) HA; and (iii) sodium chloride (NaCl). Five animals for each group were euthanized 4 weeks after the first i.a injection, while the remaining five were euthanized 8 weeks after the first i.a injection. The restoration of physiological joint microenvironment was tested by histology, histomorphometry, immunohistochemistry, and microtomography (micro-CT). At 4 and even more at 8 weeks, histological analysis showed a significant decrease in OARSI and Mankin scores, with weaker matrix metalloproteinase (MMP)-3, MMP-13, and Galectin-3 in ARTY-DUO® group versus NaCl and HA groups. A reducti...Continue Reading

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Citations

Mar 15, 2020·Journal of Biomedical Materials Research. Part a·Francesca ScognamiglioEleonora Marsich
Jul 28, 2020·Cells·G AbatangeloP Brun
Sep 11, 2020·BioMed Research International·J Raúl Olmos-ZuñigaMario Enrique Baltazares-Lipp
Jan 30, 2021·Tissue Engineering and Regenerative Medicine·Donggang MouXuming Yang

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