PMID: 9426045Jan 13, 1998Paper

Effects of intracavitary blood flow and electrode-target distance on radiofrequency power required for transient conduction block in a Langendorff-perfused canine model

Journal of the American College of Cardiology
T A SimmersR N Hauer

Abstract

We sought to quantify the effects of electrode-target distance and intracavitary blood flow on radiofrequency (RF) power required to induce transient conduction block, using a Langendorff-perfused canine ablation model. Given the thermally mediated nature of RF catheter ablation, cooling effects of intracavitary blood flow and electrode-target distance will influence lesion extension and geometry and electrophysiologic effects. In eight Langendorff-perfused canine hearts, the right ventricular free wall was opened, and the right bundle branch (RBB) carefully localized by multielectrode activation mapping. The right atrium was paced at cycle length of 500 ms. Proximal and distal electrodes were attached at the endocardial aspect of the RBB, and the perfused heart was submerged in heparinized blood at 37 degrees C. A standard 4-mm tip ablation electrode was positioned at a constant contact pressure of 5 g between the two electrodes at the site of maximal RBB potential (0 mm) and 2 and 4 mm distant from this site along a line perpendicular to the RBB. RF pulses (500 kHz) were delivered for 30 s at 0.5-W increments until transient bundle branch block. In four hearts, intracavitary flow was simulated by directing a 30-cm/s jet of bl...Continue Reading

References

Dec 1, 1991·Journal of the American College of Cardiology·J A Yeung-Lai-WahC R Kerr
Oct 1, 1989·Circulation·F H WittkampfE O Robles de Medina
Mar 1, 1994·Pacing and Clinical Electrophysiology : PACE·T A SimmersE O Robles de Medina
May 1, 1995·Journal of the American College of Cardiology·T A SimmersR N Hauer
Feb 1, 1995·Pacing and Clinical Electrophysiology : PACE·F H WittkampfE O Robles de Medina
May 1, 1994·Journal of the American College of Cardiology·D L CogginsM M Scheinman

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Citations

Mar 3, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Antoine Da CostaKarl Isaaz
Jul 14, 2006·Journal of Cardiovascular Electrophysiology·Marmar VaseghiKalyanam Shivkumar
Oct 21, 2009·Journal of Cardiovascular Electrophysiology·Michael Koa-WingPrapa Kanagaratnam
May 10, 2007·Expert Review of Medical Devices·Amir Abdelwahab, John L Sapp
Jul 25, 2003·Pacing and Clinical Electrophysiology : PACE·Helen Høgh Petersen, Jesper Hastrup Svendsen
Jun 23, 2018·JACC. Clinical Electrophysiology·Nilshan AriyarathnaGregory F Michaud

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