PMID: 6408604Apr 1, 1983Paper

Effects of intracellular calcium injection on steady state membrane currents in isolated single ventricular cells

Pflügers Archiv : European journal of physiology
H Matsuda

Abstract

The effect of intracellular calcium injection on steady state membrane currents was studied in isolated guinea-pig ventricular cells with a single-electrode voltage clamp method. When the membrane potential was clamped at the resting potential, an intracellular injection of Ca induced an inward current. The steady state current-voltage (I-V) curves before and after Ca injection crossed at around -22 mV. Above this potential, Ca increased the current in the outward direction. A linear relationship was observed between the current mediated by the increase of intracellular Ca and membrane potentials from -60 to +10 mV. This current component may correspond to the Ca-activated non-selective cation channels recorded by the patch clamp technique (Colquhoun et al., 1981).

References

Jan 1, 1978·Annual Review of Biophysics and Bioengineering·R W Meech
Apr 28, 1978·Annals of the New York Academy of Sciences·O H Peterson, N Iwatsuki
Oct 19, 1977·Pflügers Archiv : European journal of physiology·G Isenberg
Oct 19, 1977·Pflügers Archiv : European journal of physiology·G Isenberg
Jul 1, 1975·Journal of Neurobiology·W A Wilson, M M Goldner
Nov 1, 1980·The Journal of Physiology·A L Gorman, M V Thomas

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Citations

Sep 1, 1995·Pflügers Archiv : European journal of physiology·K R SipidoE Carmeliet
Mar 1, 1986·Pflügers Archiv : European journal of physiology·T Kiyosue, M Arita
Jan 5, 2000·The Journal of Physiology·Y Wu, M E Anderson
Jan 1, 1988·Annals of the New York Academy of Sciences·L H OpieF T Thandroyen
Jul 26, 2005·Pharmacology & Therapeutics·Penelope A Boyden, Henk ter Keurs
Oct 13, 2005·American Journal of Physiology. Heart and Circulatory Physiology·J Andrew Wasserstrom, Gary L Aistrup
Apr 13, 2007·Physiological Reviews·Henk E D J Ter Keurs, Penelope A Boyden
Feb 1, 1989·The American Journal of Physiology·E NiggliR Weingart
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Manabu NishioJ Andrew Wasserstrom

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