PMID: 2118725Sep 1, 1990Paper

Effects of intracellular calcium on proximal bicarbonate absorption

The American Journal of Physiology
F Y Liu, M G Cogan

Abstract

Using in vivo microperfusion in the proximal convoluted tubule (PCT) of the Munich-Wistar rat, we assessed the impact of raising intracellular calcium concentration on bicarbonate transport and its regulation by angiotensin II. Luminal perfusion with the calcium ionophore A23187 caused a dose-dependent increase in S1 PCT bicarbonate absorption, with a maximal change of 60 peq.mm-1.min-1. Subsequent addition of phorbol ester (PMA) after A23187 further increased transport but to a level no higher than previously shown with PMA alone, and A23187 was nonstimulatory when added after PMA. These results suggest that intracellular calcium affects the same pathway as protein kinase C in stimulating proximal acidification. Pretreatment with A23187 (+/- PMA) attenuated by approximately one-third the bicarbonate absorptive response in the S1 PCT usually observed after angiotensin II administration. A23187 had similar actions, but of smaller magnitude, in the S2 PCT. In conclusion, a rise in intracellular calcium increases bicarbonate absorption in the S1 and S2 PCT in vivo.

Citations

Jun 19, 2003·American Journal of Physiology. Renal Physiology·Patrice BouyerWalter F Boron

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.