Effects of intracellular diphosphonates on cells of the mononuclear phagocyte system: in vivo effects of liposome-encapsulated diphosphonates on different macrophage subpopulations in the spleen

Calcified Tissue International
N Van Rooijen, N Kors

Abstract

The intracellular effects of different diphosphonates on splenic macrophages were compared after intravenous injection of liposomes with encapsulated dichloromethylene diphosphonate (C12MDP), 3-amino-1-hydroxypropane-1,1-diphosphonate (APD), or 1 hydroxyethane-1,1-diphosphonate (EHDP) in similar concentrations. Intracellular C12MDP was by far the most toxic compound for macrophages in the spleen. APD encapsulated in liposomes in the highest possible concentration eliminated marginal zone macrophages only and EHDP did not affect any of the macrophage subpopulations in the spleen.

References

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Citations

Jul 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M J RogersF H Ebetino
Sep 18, 2009·Cancer Immunology, Immunotherapy : CII·Scott HafemanSteven Dow
Nov 13, 1989·Journal of Immunological Methods·N Van Rooijen
Dec 1, 1992·Journal of Pharmacological and Toxicological Methods·N van Rooijen, A Poppema
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May 20, 2005·Cell and Tissue Research·Takuma SaitoMakoto Naito
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Aug 1, 2015·Journal of Clinical Lipidology·Konstantin A KrychtiukWalter S Speidl
Apr 4, 2006·Biochemical and Biophysical Research Communications·Tomomi Ishikawa-SekigamiTakashi Matozaki
Sep 19, 2014·International Journal of Oncology·Hideki MatsumuraNobuhiro Ohkohchi
Oct 7, 2017·Frontiers in Cellular and Infection Microbiology·Janaiara A CunhaCláudio Tadeu Daniel-Ribeiro

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