PMID: 6414007Jan 1, 1983Paper

Effects of intracerebroventricular administration of prostaglandin D2 on behaviour, blood pressure and body temperature as compared to prostaglandins E2 and F2 alpha

Psychopharmacology
U FörstermannG Hertting

Abstract

The present work examined some central nervous actions of prostaglandin D2 (PGD2), which is the most prevalent prostaglandin in rodent brain. The effects of PGD2 were compared with those of PGE2 and PGF2 alpha. The prostaglandins were administered intracerebroventricularly (ICV) to conscious rats using the method of Herman (1970). All three prostaglandins studied produced depressive behavioral effects, causing obvious sedation at doses of 2.0 micrograms and 20.0 micrograms ICV. PGD2 and PGE2 significantly reduced spontaneous motor activity at doses of 2.0 micrograms and 20.0 micrograms ICV. PGF2 alpha was less effective; only 20.0 micrograms significantly inhibited motor activity. At a dose of 20.0 micrograms ICV all three compounds were shown to block convulsions induced by pentylenetetrazol. PGD2, the most effective prostaglandin in this respect, was still slightly anticonvulsive at a dose of 2.0 micrograms ICV. PGF2 alpha hat the weakest anticonvulsive potency. PGE2 and PGF2 alpha (2.0 micrograms and 20.0 micrograms ICV) caused a marked hypertensive effect, whereas PGD2 at the same dose levels only produced a small increase in blood pressure. PGE2 and PGF2 alpha (2.0 micrograms and 20.0 micrograms) also exerted marked pyroge...Continue Reading

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Citations

Nov 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·Y MasudaM Shimizu
Feb 14, 1987·Biochimica Et Biophysica Acta·F SuzukiO Hayaishi
Feb 15, 1988·Biological Psychiatry·K OhishiO Hayaishi
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Mar 6, 1989·Brain Research·H MatsumuraO Hayaishi
Mar 11, 1992·Physiology & Behavior·J M KruegerF Obál
Mar 1, 1987·Pharmacology, Biochemistry, and Behavior·R SaitoN Ono
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·P E WainwrightJ Hammond
Jun 1, 1985·Prostaglandins, Leukotrienes, and Medicine·U FörstermannG Hertting
Apr 29, 1998·Epilepsy Research·E S AkarsuA Comert
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H OnoeO Hayaishi
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H MatsumuraO Hayaishi
Mar 15, 2008·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ryan J Van Lieshout, Glenda Macqueen
Dec 12, 2012·The Journal of Experimental Biology·Robert H McCusker, Keith W Kelley
Jan 1, 1989·Annals of the New York Academy of Sciences·G Hertting, A Seregi
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Sep 17, 2015·Advances in Nutrition·Melissa GabbsHarold M Aukema
Jan 1, 1993·Neuroscience and Biobehavioral Reviews·H Moltz

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