Effects of intracerebroventricular administration of PGE1, E2 and F2alpha on electrically induced convulsions in mice

Prostaglandins
R P Rosenkranz

Abstract

Intracerebroventricular administration of prostaglandins E1 or E2 was shown to block, while PGF2alpha increased the incidence of tonic convulsion due to electroshock in mice. The Prostaglandins were administered intracerebroventicularly (i.c.v.) to conscious mice by a modification of Haley and McCormick's method (1) prior to a transcorneal maximal electroshock (MES) or a transcorneal supra-maximal electroshock (SMES). PGE1 and PGE2 i.c.v. blocked the tonic hindlimb extension (THE) and protected the animals from death induced by MES with ED50's for PGE1 and PGE2 for inhibition of the THE of 6.6 (4.3--12.0) microgram/mouse i.c.v. and 13.3 (8.9--22.4) microgram/mouse i.c.v. respectively. When PGE2 was administered intraperitoneally (i.p.) in doses as high as 4.0 mg/kg it did not block the THE. However, the duration of the THE as well as the mortality were reduced by doses of 0.5--4.0 mg/kg PGE2 i.p.. Both PGE1 and PGE2 were shown to cause a dose related significant (p less than .001) decrease in the duration of the THE with SMES in doses of 1--10 microgram/mouse i.c.v. for PGE1 and 2--40 microgram/mouse i.c.v. for PGE2. PGF2alpha, administered i.c.v. prior to a transcorneal electroshock equivalent to a current at the ED1 level, in...Continue Reading

References

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Aug 1, 1972·Prostaglandins·D P Gilmore, A A Shaikh
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Citations

Jan 16, 1981·European Journal of Pharmacology·H B Steinhauer, G Hertting
Apr 1, 1980·Prostaglandins and Medicine·J Lieb
Jan 1, 1981·Progress in Lipid Research·R P Rosenkranz, K F Killam
Jun 15, 1984·Brain Research·S Divinetz RomeroT L Yaksh
Apr 1, 1982·Journal of Neurochemistry·T W Lysz, P Needleman
Dec 1, 1986·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M K StevensR E Anderson
Apr 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·E NavarroT L Yaksh
Dec 1, 1984·Journal of Neurochemistry·S D RomeroT L Yaksh

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