Effects of intracerebroventricular corticotropin releasing factor on sensory-evoked responses in the rat visual thalamus

Brain Research
Gerard A ZitnikBarry D Waterhouse

Abstract

Corticotropin releasing factor (CRF) coordinates the brain׳s responses to stress. Recent evidence suggests that CRF-mediated activation of the locus coeruleus-norepinephrine (LC-NE) system contributes to alterations in sensory signal processing during stress. However, it remains unclear whether these actions are dependent upon the degree of CRF release. Using intracerebroventricular (ICV) infusions, we examine the dose-dependent actions of CRF on sensory-evoked discharges of neurons in the dorsal lateral geniculate nucleus of the thalamus (dLGN). The LGN is the primary relay for visual signals from retina to cortex, receiving noradrenergic modulation from the LC. In vivo extracellular recording in anesthetized rats was used to monitor single dLGN neuron responses to light flashes at three different stimulus intensities before and after administration of CRF (0.1, 0.3, 1.0, 3.0 or 10.0 μg). CRF produced three main effects on dLGN stimulus evoked activity: (1) increased magnitude of sensory evoked discharges at moderate doses, (2) decreased response latency, and (3) dose-dependent increases in the number of cells responding to a previously sub-threshold (low intensity) stimulus. These modulatory actions were blocked or attenuated...Continue Reading

References

Jun 10, 2017·Neural Plasticity·Olga BorodovitsynaDaniel Chandler

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Related Concepts

Neuro-Oncological Ventral Antigen 2
Optic Tract Structure
Biochemical Pathway
Corticotropin Releasing Hormone Measurement
Microelectrodes
Biological Adaptation to Stress
Photopsia
Cortex Bone Disorders
Adrenal Cortex Diseases
Body Parts - Cannula

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