Effects of intracerebroventricular floctafenine and indomethacin on body temperature in febrile rabbits

British Journal of Pharmacology
H LaburnJ Stephen

Abstract

1. We injected the potent prostaglandin synthesis inhibitors, floctafenine and indomethacin, intravenously and intracerebroventricularly in rabbits made febrile by intravenous injection of leucocyte pyrogen. 2. Floctafenine (75 mumol) injected intravenously failed to affect the fever, whereas indomethacin (15 mumol) markedly reduced the fever. 3. When injected into the cerebral ventricles, floctafenine was feebly antipyretic, and then only at a dose ten times the antipyretic dose of indomethacin. 4. Our results support the suggestion that floctafenine has no antipyretic action when administered peripherally. However, its lack of antipyretic effect cannot be explained solely on the grounds that it fails to cross the blood-brain barrier.

References

Jul 1, 1976·The Journal of Physiology·W I CranstonY Townsend
May 1, 1977·The Journal of Physiology·H LaburnC Rosendorff
Aug 1, 1979·Annals of Internal Medicine·H A BernheimE Atkins
Jan 1, 1979·General Pharmacology·W G Clark
Jun 1, 1978·The Journal of Physiology·D BorsookD Mitchell
May 15, 1974·Biochemical Pharmacology·R J Flower, J R Vane
Mar 1, 1971·The American Journal of Physiology·C Rosendorff, J J Mooney

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Citations

Dec 1, 1991·Pflügers Archiv : European journal of physiology·M Hashimoto
Mar 1, 1994·Agents and Actions·V NeugebauerR F Schmidt
Jan 1, 1995·Fundamental & Clinical Pharmacology·B BannwarthJ Dehais

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