Effects of intracerebroventricular insulin microinjection on renal sodium handling in kidney-denervated rats

Brain Research Bulletin
J B MichelottoJ A Gontijo

Abstract

The role of the central nervous system (CNS) in the control of hydrosaline homeostasis has been strikingly demonstrated by several studies. Growing evidence suggests that insulin may exert an influence in the modulation of many brain functions. However, there are no available data examining the CNS effect of insulin injection on renal sodium handling. Also, to examine the influence of renal nerve activity during i.c.v. administration of insulin, unanesthetized, unrestrained rats were randomly assigned to one of nine separated groups: (a) sham-operated i.c.v. 0.15 M NaCl-injected (Co, pooled data, n = 37) and sham-operated i.c.v. 0.42 ng. microl(-1) (n = 12), 4.2 ng.microl(-1) (n = 10) and 42.0 ng.microl(-1) (n = 11) insulin-injected rats (In); (b) renal-denervated i.c.v. 0.15 M NaCl (Co(Dx), n = 5), and insulin-injected rats (In(Dx), n = 5); and (c) subcutaneously insulin-injected rats (SC, n = 5). We showed that centrally administered insulin produced dose-related increased urinary output of sodium [Co: 855 +/- 85 Delta% min, 0.42 ng.microl(-1) In: 1189 +/- 308 Delta% min, 4.2 ng.microl(-1) In: 1461 +/- 594 Delta% min (p = 0.048), and 42.0 ng.microl(-1) In: 2055 +/- 411 Delta% min (p = 0.0001)], and dose-independently increase...Continue Reading

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Citations

Sep 18, 2010·The Journal of Physiological Sciences : JPS·Adriana ZapparoliJosé Antonio Rocha Gontijo
Jan 25, 2011·The Journal of Biological Chemistry·Vivian C CalegariLício A Velloso
Aug 25, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Patrícia Aline BoerJosé A R Gontijo
Aug 7, 2013·Molecular and Cellular Endocrinology·G A SantosM A Torsoni
Oct 30, 2010·Clinical and Experimental Hypertension : CHE·José Antonio Rocha GontijoBenedito Borges Da Silva
Aug 26, 2003·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R F MacedoJ A R Gontijo
Jun 2, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Silmara CiamponeJosé A R Gontijo
Mar 12, 2011·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Adriana ZapparoliJosé Antonio Rocha Gontijo
Mar 20, 2003·American Journal of Physiology. Endocrinology and Metabolism·Márcio A TorsoniLício A Velloso
Sep 1, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Marcelo Cardoso de LimaJosé Antonio Rocha Gontijo
Aug 25, 2009·Molecular and Cellular Endocrinology·Erika A F R RomanMarcio A Torsoni

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