Effects of intraduodenal glucose concentration on blood pressure and heart rate in healthy older subjects.

Digestive Diseases and Sciences
D GentilcoreKaren L Jones

Abstract

The aims of this study were to determine whether the hypotensive and heart rate responses to small intestinal glucose infusion are dependent on the glucose concentration. Eight healthy subjects, aged 65-78 years, were studied on 3 separate days in random order. Each subject received intraduodenal infusions of 50 g of glucose in either 300 mL (16.7%), 600 mL (8.3%), or 1200 mL (4.1%) of saline (0.9%) at a rate of 3 kcal/min for 60 minutes (t = 0-60 minutes), followed by saline (0.9%) for a further 60 minutes (t = 60-120 minutes). During the infusions, blood pressure (systolic and diastolic) and heart rate were measured every 3 minutes, and blood glucose concentrations every 15 minutes. Systolic and diastolic blood pressure fell (P < .0001), and heart rate and blood glucose increased (P = .0001 for both) over time, during all 3 infusions. Between t = -2-120 minutes, there was no difference in systolic blood pressure (P = .20), diastolic blood pressure (P = .61), or heart rate (P = .09) over the study days. There was also no significant difference in the glycemic response to the infusions. We conclude that in healthy older subjects, glucose concentration does not affect the blood pressure or heart rate responses to intraduodenal g...Continue Reading

References

Sep 1, 1976·The American Journal of Physiology·J H MeyerR S Jones
Dec 1, 1991·Journal of the American Geriatrics Society·R W Jansen, W H Hoefnagels
Dec 1, 1989·Journal of the Neurological Sciences·C J MathiasN J Christensen
Aug 1, 1988·The American Journal of Clinical Nutrition·J H MeyerI L Taylor
Nov 1, 1987·The American Journal of Cardiology·R W JansenW H Hoefnagels
Oct 1, 1970·The American Journal of Physiology·J H MeyerM I Grossman
Jul 1, 1966·The American Journal of Digestive Diseases·J S Fordtran, T W Locklear
May 1, 1984·The British Journal of Nutrition·H A JarjisN W Read
Mar 1, 1984·Clinical Science·N A BlackburnN W Read
Oct 2, 1982·British Medical Journal·D J Ewing, B F Clarke
Feb 15, 1995·Annals of Internal Medicine·R W Jansen, L A Lipsitz
Jun 1, 1996·American Journal of Hypertension·K MasuoM L Tuck
Sep 20, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·F PuisieuxP Dewailly
Feb 24, 2001·Journal of the American Geriatrics Society·K L JonesM Horowitz
Nov 28, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L C VloetR W Jansen
Mar 21, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A Timar-PeregrinJ B Furness
Mar 21, 2002·The American Journal of Medicine·John R ShannonJens Jordan
Apr 17, 2002·The Journal of Physiology·Deirdre O'DonovanKaren Louise Jones
Jul 23, 2003·Digestive Diseases and Sciences·Antonietta RussoKaren L Jones
Mar 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Karen L JonesMichael Horowitz
Aug 5, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Deirdre O'DonovanKaren Louise Jones

❮ Previous
Next ❯

Citations

Mar 15, 2011·The British Journal of Nutrition·Kamilia TaiIan M Chapman
Jun 2, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Diana GentilcoreKaren L Jones
Feb 1, 2008·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Narender P van OrshovenP Liam Oey
Mar 19, 2014·Journal of the American Medical Directors Association·Laurence G TrahairKaren L Jones
Jul 28, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Diana GentilcoreKaren L Jones
May 23, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Diana GentilcoreKaren L Jones
Jun 26, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Diana GentilcoreKaren L Jones
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lora VanisKaren L Jones
Mar 11, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lora VanisKaren L Jones
Aug 9, 2019·The Journal of Clinical Endocrinology and Metabolism·Hung PhamKaren L Jones
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved