PMID: 6170415Nov 15, 1981Paper

Effects of intralesional interferon on neuroblastoma: changes in histology and DNA content distribution of tumor masses

Cancer
T SawadaT Kishida

Abstract

Local injections of interferon, 30 X 10(4) IU, ten times, were found to reduce masses of neuroblastoma. Histologic findings and nuclear DNA measurements of cells from tumors in which interferon has been injected compared with cells from tumors that did not receive injections demonstrated that the reduction of neuroblastoma masses by interferon did not depend on increased cell differentiation or on interruption of tumor cell production. Although the mechanism of interferon's action on reducing neuroblastoma is unknown, the disappearance of tumor cells may be caused by high levels of interferon in tumor tissues.

References

Dec 28, 1978·The New England Journal of Medicine·T C MeriganS A Rosenberg
Jan 1, 1976·Acta Medica Scandinavica·H BlomgrenH Strander
Oct 1, 1970·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H P Wagner, H Käser
Jun 1, 1968·American Journal of Diseases of Children·J Whang-Peng, J M Bennett

❮ Previous
Next ❯

Citations

Oct 1, 1983·Cancer·T TanakaT Kusunoki
Jan 1, 1986·Medical Oncology and Tumor Pharmacotherapy·I Gresser

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.