Effects of intranasal inoculation with Bordetella bronchiseptica, porcine reproductive and respiratory syndrome virus, or a combination of both organisms on subsequent infection with Pasteurella multocida in pigs

American Journal of Veterinary Research
Susan L BrockmeierR B Rimler

Abstract

To determine effects of intranasal inoculation with porcine reproductive and respiratory syndrome virus (PRRSV) or Bordetella bronchiseptica on challenge with nontoxigenic Pasteurella multocida in pigs. Seventy 3-week-old pigs. In experiment 1, pigs were not inoculated (n= 10) or were inoculated with PRRSV (10), P. multocida (10), or PRRSV followed by challenge with P. multocida (10). In experiment 2, pigs were not inoculated (n = 10) or were inoculated with B. bronchiseptica (10) or PRRSV and B. bronchiseptica (10); all pigs were challenged with P. multocida. Five pigs from each group were necropsied 14 and 21 days after initial inoculations. Pasteurella multocida was not isolated from tissue specimens of pigs challenged with P. multocida alone or after inoculation with PRRSV. However, in pigs challenged after inoculation with B. bronchiseptica, P. multocida was isolated from specimens of the nasal cavity and tonsil of the soft palate. Number of bacteria isolated increased in pigs challenged after coinoculation with PRRSV and B. bronchiseptica, and all 3 agents were isolated from pneumonic lesions in these pigs. Infection of pigs with B. bronchiseptica but not PRRSV prior to challenge with P. multocida resulted in colonization...Continue Reading

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Citations

Dec 14, 2011·Animal Health Research Reviews·T OpriessnigP G Halbur
Jun 16, 2004·Nature Reviews. Microbiology·Lauren O Bakaletz
May 20, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Christopher S RogersMichael J Welsh
Jul 12, 2014·Genome Announcements·Tracy L NicholsonRobert A Kingsley
Nov 21, 2007·Veterinary Microbiology·S L BrockmeierM V Palmer
Oct 28, 2004·Veterinary Immunology and Immunopathology·Steven Van GuchtKristien Van Reeth
Jun 13, 2018·Journal of Morphology·Yunhan YangQian Yang
Apr 8, 2020·Porcine Health Management·P ObaM M Dione
Jan 25, 2020·Microbiology Resource Announcements·Tracy L NicholsonSarah M Shore
Nov 26, 2016·Journal of Veterinary Pharmacology and Therapeutics·J W SparksJ F Coetzee
Mar 4, 2008·The Veterinary Record·A PalzerK Heinritzi

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