PMID: 737162Dec 1, 1978Paper

Effects of intraocular miotics on cultured bovine corneal endothelium

The British Journal of Ophthalmology
J L Jay, M MacDonald

Abstract

Two cases of severe corneal oedema occurred after the use of intraocular pilocarpine. Experimental investigations were conducted with cultured bovine corneal endothelial cells exposed for 5 minutes to 1% pilocarpine solutions of varying composition. Cells were destroyed in solutions not isotonic with aqueous humour, and calcium-free ionic solutions caused loss of cell adhesion without loss of viability. Low pH or the presence of 1% pilocarpine had no detectable effects; 1% acetylcholine chloride in 5% mannitol (Miochol) also caused cell destruction, and this preparation was found to be considerably hypertonic. The minimum requirements for the formulation of intraocular miotics are discussed.

References

Jul 1, 1977·Investigative Ophthalmology & Visual Science·D Maurice, M Perlman
Feb 1, 1975·American Journal of Ophthalmology·D S HullR A Hyndiuk
Jan 1, 1975·Archives of Ophthalmology·W H Coles
Apr 1, 1976·American Journal of Ophthalmology·H F EdelhauserR A Hyndiuk
Aug 1, 1968·The British Journal of Ophthalmology·R A Anderson, J B Cowle
Nov 1, 1958·American Journal of Ophthalmology·F W STOCKERN GEORGIADE

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Citations

Jan 1, 1987·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S D CookS M Brown
Aug 15, 1993·American Journal of Ophthalmology·M R GrimmettH F Edelhauser
Sep 29, 2000·Journal of Cataract and Refractive Surgery·H B DickN Pfeiffer
Jan 1, 1986·Journal of Cataract and Refractive Surgery·R W Yee, H F Edelhauser
Oct 10, 1996·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·J Schumann-Anderson
Jun 1, 1996·Journal of Cataract and Refractive Surgery·R W YeeG Kozielec
Mar 1, 1993·Journal of Cataract and Refractive Surgery·T M LangeB J McLaughlin

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