PMID: 6406401Apr 1, 1983Paper

Effects of intraoperative electron irradiation in the dog on cell turnover in intact and surgically-anastomosed aorta and intestine

International Journal of Radiation Oncology, Biology, Physics
W F SindelarR E Terrill

Abstract

Adult dogs were subjected to laparotomy and intraoperative electron irradiation after division and reanastomosis of aorta or after construction of a blind loop of small intestine having a transverse suture line and an end-to-side anastomosis. Dogs received intraoperative irradiation of both intact and anastomosed aorta or intestine in doses of 0, 2000, 3000, or 4500 rad. Animals were sacrificed at seven days or three months following treatment. At 24 hours prior to sacrifice, dogs received 5 mCi tritiated thymidine intravenously. Irradiated and non-irradiated segments of aorta and small intestine, including intact and anastomotic regions, were analyzed for tritiated thymidine incorporation and were subjected to autoradiography. Incorporation studies showed diminution in tritiated thymidine uptake by irradiated portions of aorta and small intestine, in both intact and anastomotic regions. Autoradiograms revealed that irradiated areas of intact or anastomotic aorta or intestine had diminished labeling of stromal cells, suggesting a lowered cell proliferative capacity of irradiated tissue compared to non-irradiated portions. Inflammatory cells showed similar labeling indices in irradiated and non-irradiated tissues, both intact an...Continue Reading

References

Dec 1, 1974·Cancer·M AbeK Mori
Nov 1, 1982·Annals of Surgery·W F SindelarR Terrill
Jul 1, 1981·International Journal of Radiation Oncology, Biology, Physics·M Abe, M Takahashi
Oct 1, 1980·Diseases of the Colon and Rectum·A M CohenW C Wood

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Citations

Feb 1, 1995·Diseases of the Colon and Rectum·J L McCueR K Phillips
Sep 1, 1986·International Journal of Radiation Oncology, Biology, Physics·J E TepperJ K Martin
Mar 1, 1996·International Journal of Radiation Oncology, Biology, Physics·P A JohnstoneW F Sindelar
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·G E Hanks, R M Lanciano
Sep 1, 1990·International Journal of Radiation Oncology, Biology, Physics·M BarnesT Kinsella
Dec 1, 1993·International Journal of Radiation Oncology, Biology, Physics·J BiertJ Hoogenhout
May 1, 1983·Current Problems in Cancer·L L GundersonW C Wood
Nov 1, 1987·Journal of Surgical Oncology·H J HoekstraJ Oldhoff
Jul 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·T A Rich

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