Effects of Intraoperative Opioid Use on Recurrence-Free and Overall Survival in Patients With Esophageal Adenocarcinoma and Squamous Cell Carcinoma

Anesthesia and Analgesia
Kim N DuJuan P Cata

Abstract

Perioperative opioid use is associated with poor survival in patients with esophageal squamous cell carcinoma. The most common histological type of esophageal cancer in western countries is adenocarcinoma. The objective of this study was to evaluate the association between intraoperative opioid consumption and survival in patients with adenocarcinoma and squamous cell carcinoma of the esophagus. Records of patients who had undergone esophageal cancer surgery between January 2000 and January 2017 were reviewed. Comparisons were made between patients who received high versus low intraoperative doses of opioids. Groups were divided using the recursive partitioning method. Multicovariate Cox proportional hazards models were fitted to evaluate the impact of intraoperative opioid use on recurrence-free survival (RFS) and overall survival (OS). For patients with esophageal squamous cell carcinoma, the univariable analysis indicated that lower opioid dosages (<710 μg fentanyl equivalents) were significantly associated with worse RFS (P = .009) and OS (P = .002). With the adjustment of age, stage, and adjuvant chemotherapy, multivariable analysis confirmed significant associations between higher dosages of intraoperative fentanyl equiva...Continue Reading

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Citations

Jul 30, 2019·Critical Care Medicine·Wen-Kuei ChangKuang-Yi Chang
Sep 12, 2019·Acta Anaesthesiologica Scandinavica·Eric AlbrechtKyle R Kirkham
Nov 7, 2019·Pain·Diane M NovyKalpna Gupta
Feb 6, 2020·International Anesthesiology Clinics·Maria F RamirezJuan P Cata
Jul 20, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Gary DevineAndrew Roscoe
Nov 23, 2020·British Journal of Anaesthesia·Giacomo MontagnaJoshua S Mincer
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Oct 13, 2021·Pain Management·Maria F RamirezJuan P Cata
Oct 19, 2021·The Annals of Thoracic Surgery·Jean SelimVincent Compère

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