Effects of intraoperative sponge mitomycin C and 5-fluorouracil on scar formation following strabismus surgery in rabbits

Strabismus
Arif EşmeSerap Ozden

Abstract

To investigate the influence of 5-fluorouracil (5-FU) and mitomycin C (MMC) on the postoperative adhesions following strabismus surgery in rabbits. Twenty-one New Zealand white rabbits were used in this prospective, masked, controlled trial. Both eyes of 20 animals underwent 3-mm recession of the superior rectus muscle (SRM). In group I (io animals), one eye of each animal received topical application of MMC (0.2 mg/ml) for 5 minutes and the other eye (control eye) was treated with balanced salt solution (BSS) using an intraoperative sponge. In group II (10 animals), a randomly chosen eye of each animal was treated with 5-FU soaked sponges (50 mg/ml) for 5 minutes and the fellow eye (control eye) with BSS. Two eyes of a rabbit were included as unoperated controls. Four weeks after the surgery, conjunctival vascularity and postoperative adhesions between the SRM Tenon's capsule (TC) and SRM sclera (scl) were assessed. Additionally, eyes were enucleated and evaluated histopathologically for evidence of scarring, granuloma formation, and muscle tissue changes under a light microscope. MMC-treated eyes had a higher rate of avascular conjunctiva compared to both controls and 5-FU-treated eyes. Mean adhesion scores, particularly betw...Continue Reading

References

Mar 1, 1974·The British Journal of Ophthalmology·E A Dunlap
Jul 1, 1983·Journal of Clinical Pathology·G T Williams, W J Williams
Sep 15, 1994·American Journal of Ophthalmology·S SmithE B Dreyer
Jun 1, 1997·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·J S MoraA P Evan

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Citations

Jul 16, 2014·Journal of Endourology·Ugur UyeturkMehmet Emin Ozyalvacli
Feb 5, 2011·Ophthalmology·Yi Ning J StrubeKenneth W Wright
Jun 18, 2009·British Journal of Neurosurgery·Berker CemilIbrahim Tekdemir
Feb 8, 2007·Drugs·Lekha M AbrahamIgal Leibovitch
Jul 1, 2016·Taiwan Journal of Ophthalmology·Seyhan B Özkan
Dec 7, 2020·Experimental Eye Research·José Álvaro Pereira Gomes, José Arthur Pinto Milhomens Filho

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