Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory

Neurobiology of Learning and Memory
M G PackardNicolas G Bazan

Abstract

The present experiments examined the effects of posttraining intra-dorsal striatal (i.e., caudate-putamen) injections of the phospholipid methylcarbamyl platelet-activating factor (mc-PAF) and the platelet-activating factor (PAF) antagonist BN 52021 on memory using a striatal-dependent cued water maze task. Male Long-Evans rats received an eight-trial training session in which a visibly cued escape platform was located in a different quadrant of the maze on each trial, followed by an intrastriatal injection of mc-PAF (0.5, 1.0, or 2.0 micrograms/0.5 microliter), BN 52021 (0.25, 0.5, or 1.0 microgram/0.5 microliter), or vehicle (DMSO; 0.5 microliter). On a retention test 24 h later, the escape latencies of rats given mc-PAF (1.0, 2.0 micrograms) wee significantly lower than those of vehicle-injected controls, indicating a memory enhancing effect of mc-PAF. The retention test escape latencies of rats given BN 52021 (0.5, 1.0 microgram) were significantly higher than those of vehicle-injected controls, indicating a memory impairing effect of BN 52021. Injections of mc-PAF or BN 52021 did not affect retention when administered 2-h posttraining, indicating a time-dependent effect of the drugs on memory storage. The findings indicate...Continue Reading

Citations

Dec 21, 2002·The European Journal of Neuroscience·Lisa A TeatherRichard J Wurtman
Mar 28, 2002·Learning & Memory·Lisa A TeatherNicolas G Bazan
Aug 12, 2008·BMC Pharmacology·Rajeshkumar U KoladiyaBhupesh K Sharma
Apr 7, 2010·Naunyn-Schmiedeberg's Archives of Pharmacology·Puneet RinwaNirmal Singh
Jun 21, 2015·Neurobiology of Learning and Memory·Jarid Goodman, Mark G Packard
Dec 21, 2005·Neuroscience Research·Mohammad SharifzadehAli Roghani
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Jun 26, 1998·Journal of Neurophysiology·S GrassiV E Pettorossi
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Dec 29, 2004·Journal of Neuroscience Research·Mohammad SharifzadehAli Roghani
Mar 18, 2008·Pharmacology, Biochemistry, and Behavior·Bhupesh SharmaAmteshwar Singh Jaggi

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