Effects of intravenous administration of human bone marrow stromal cells after intracerebral hemorrhage in rats

Journal of Neurosurgery
Donald M SeyfriedMichael Chopp

Abstract

The goal of this study was to investigate whether human bone marrow stromal cells (hBMSCs) administered by intravenous injection have a beneficial effect on outcome after intracerebral hemorrhage (ICH) in rats. An ICH was induced in 54 adult male Wistar rats by a stereotactically guided injection of autologous blood into the right striatum. Intravenous infusion of the hBMSCs (3, 5, or 8 million cells) was performed 1 day after ICH, and for each dose group there was a control group that received injections of vehicle. Neurological function, which was evaluated using the Neurological Severity Score (NSS) and the corner turn test, was tested before and at 1, 7, and 14 days after ICH. After 14 days of survival, the area of encephalomalacia was calculated and histochemical labeling was performed. For all three groups, there were no statistical differences in either the NSS or corner turn tests after 1 day. After 7 and 14 days, however, the three groups that received the hBMSCs showed significant improvement in functional scores compared with the control group. In addition, after 14 days there was significantly more striatal tissue loss in the placebo groups compared with each of the three treatment groups. The region of injury in th...Continue Reading

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Citations

Jun 30, 2009·Neuroradiology·Johan LundbergStaffan Holmin
Dec 7, 2007·Neurocritical Care·Michael Lucas JamesDaniel T Laskowitz
Aug 1, 2009·Stroke; a Journal of Cerebral Circulation·Kishor KarkiDonald M Seyfried
Mar 24, 2009·Journal of Neurosurgery·Michael ChoppYi Li
Mar 17, 2009·Journal of Neurosurgery·Donald M SeyfriedMichael Chopp
Mar 18, 2008·Neurosurgical Focus·Robert H AndresGary K Steinberg
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May 18, 2019·Npj Regenerative Medicine·Marion T TurnbullWilliam D Freeman
Apr 13, 2021·Frontiers in Cellular Neuroscience·Yu-Hua GongBo-Chu Wang

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