Effects of intravenous iron combined with low-dose recombinant human erythropoietin on transfusion requirements in iron-deficient patients undergoing bilateral total knee replacement arthroplasty

Transfusion
Hyo-Seok NaSang-Hwan Do

Abstract

The authors examined the impact of parenteral iron and recombinant human erythropoietin-β (rHuEPO-β) administered in the bilateral total knee replacement arthroplasty (TKRA), on postoperative anemia and transfusion requirements in iron-deficient patients. A total of 108 iron-deficient patients were randomly assigned to two groups: Group C (control) or Group IE (200 mg of iron sucrose intravenously over 1 hr and 3000 IU of rHuEPO-β subcutaneously during the operation and during the postoperative period if the hemoglobin [Hb] level was 70-80 g/L). One or 2 units of blood were transfused to patients in both groups according to postoperative Hb level (between 60 and 70 g/L or betweeen 50 and 60 g/L, respectively). Perioperative laboratory and clinical outcomes (Hb, iron variables, postoperative bleeding amount, and number of units of RBCs transfused and incidences) were documented. Although preoperative Hb and the amount of postoperative bleeding were comparable in the two groups, Hb levels at 1, 2, and 3 days and at 2 and 6 weeks postoperation were significantly higher in Group IE. Furthermore, the transfusion rate was significantly lower in Group IE (20.4% vs. 53.7%, p=0.011) and the mean number of red blood cell units transfused...Continue Reading

References

Mar 11, 1998·The Journal of Arthroplasty·M BouldJ H Newman
Feb 11, 1999·The Journal of Bone and Joint Surgery. American Volume·B E BierbaumR B Welch
Mar 27, 1999·International Orthopaedics·T K Liu, S H Chen
Apr 27, 1999·Transfusion Medicine·D CoyleA Laupacis
Jul 2, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Lawrence Tim Goodnough
Sep 19, 2002·American Journal of Therapeutics·Edward Crosby
Jun 16, 2004·Critical Care : the Official Journal of the Critical Care Forum·Terri G Monk
Jul 2, 2005·The Knee·G Senthil KumarJ L Pozo
Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gabriel MircescuNicolae Ursea
Dec 24, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Keyvan KarkoutiTerrence M Yau
Jul 13, 2006·Kidney International. Supplement·D Coyne
May 8, 2007·The Spine Journal : Official Journal of the North American Spine Society·Michael G VitaleDavid P Roye
Sep 19, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Jay B Wish
Mar 20, 2008·Anesthesia and Analgesia·Niamh P ConlonMaire McCarroll
Jul 2, 2009·The Journal of Bone and Joint Surgery. British Volume·S HuZ-D Cai
Sep 26, 2009·The Oncologist·Anatole BesarabDonald Silverberg
Sep 30, 2009·World Journal of Gastroenterology : WJG·Fernando Bermejo, Santiago García-López

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Citations

Apr 13, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Gregory M T HareKaterina Pavenski
May 28, 2013·Lancet·Donat R Spahn, Lawrence T Goodnough
May 18, 2012·British Journal of Anaesthesia·D R SpahnA Hofmann
Jan 15, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Fiona E Ralley
May 16, 2014·British Journal of Anaesthesia·D M BaronUNKNOWN European Society of Anaesthesiology
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Donat R SpahnAxel Hofmann
Apr 18, 2013·Best Practice & Research. Clinical Anaesthesiology·Gregory M T HareAryeh Shander
Nov 14, 2013·Expert Opinion on Biological Therapy·Diane H D TranMichael G Irwin
Aug 19, 2016·Hip & Pelvis·Jong Hee Lee, Seung Beom Han
Apr 6, 2013·Journal of Clinical Anesthesia·Usha Gurunathan
Jan 29, 2013·Best Practice & Research. Clinical Anaesthesiology·Sumit SinghMitchell P Fink
Mar 4, 2014·Orthopedics·Thomas BernasekEnrico M Camporesi
Oct 2, 2015·Revista brasileira de anestesiologia·Liana Maria Torres de Araujo Azi, Luis Vicente Garcia
Apr 17, 2015·British Journal of Anaesthesia·D R Spahn, K Zacharowski
Apr 26, 2016·Brazilian Journal of Anesthesiology·Liana Maria Torres de Araujo Azi, Luis Vicente Garcia
May 20, 2016·Transfusion·Máximo Bernabeu-WittelUNKNOWN PAHFRAC-01 Investigators
Jun 19, 2016·Transfusion Medicine Reviews·Patrick MeybohmKai Zacharowski
Jul 28, 2016·Archives of Orthopaedic and Trauma Surgery·You-Sung SuhKyung-Hoi Koo
Sep 8, 2011·Transfusion·Pampee P Young, Bryan A Cotton
Jun 14, 2013·Journal of the Royal Society of Medicine·Judith PartridgeJugdeep Dhesi
Nov 10, 2018·Vox Sanguinis·Susana Gómez-RamírezManuel Muñoz
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Nov 25, 2011·Current Opinion in Anaesthesiology·Aryeh Shander, Mazyar Javidroozi
May 3, 2019·Singapore Medical Journal·Hairil Rizal AbdullahUNKNOWN Asia-Pacific PBM Expert Consensus Meeting Working Group
Aug 24, 2017·BMC Musculoskeletal Disorders·Syed Hamza MufarrihShahryar Noordin

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