PMID: 9429744Jan 16, 1998Paper

Effects of intravenous lipid as a source of energy in parenteral nutrition associated hepatic dysfunction and lidocaine elimination: a study using isolated rat liver perfusion

Biopharmaceutics & Drug Disposition
N ZamanR T Coutts

Abstract

The effects on liver function and hepatic lidocaine elimination using 20% Intralipid as a source of non-protein calories (30%) in parenteral nutrition were studied using an isolated rat liver perfusion procedure. Rats were randomly assigned to one of the three treatment groups: PNL group (n = 6), consisting of 16.94% dextrose, 2.46% Intralipid, and 5.2% amino acids; PN group (n = 5), consisting of 24.2% dextrose and 5.2% amino acids; and CF group (n = 6), chow fed (rat chow and water). The rate of lidocaine metabolism was significantly reduced after 7 d in the two PN treated groups when compared to CF. Steatosis was observed in five out of six PNL treated animals and two out of five PN treated animals. Intrinsic clearance was reduced by 80% in the PNL group and by 60% in the PN animals (p < 0.05). Molar metabolite to drug ratios revealed significant reductions in N-dealkylation, m-hydroxylation, and aryl methyl hydroxylation in groups PNL and PN; these values amounted to 67-92% (p < 0.05). These findings suggest that a dextrose-amino acid solution induced steatosis and reduced the rate of lidocaine metabolism. The incorporation of Intralipid caused further deterioration.

Citations

Jul 12, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Maitreyi Raman, Johane P Allard
Feb 12, 2002·Pharmacotherapy·Imad F Btaiche, Nabil Khalidi
Feb 20, 2014·BioMed Research International·Bassam Abu-Wasel, Michele Molinari
Apr 2, 2011·Journal of Perinatology : Official Journal of the California Perinatal Association·K T ParkJ Kerner
Sep 29, 2009·Seminars in Pediatric Surgery·Ivan R DiamondPaul W Wales
Feb 14, 2006·Gastroenterology·Deirdre A Kelly
Jul 7, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Deepika NehraMark Puder
Jan 26, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Gertrud AngstenHelene Engstrand Lilja
Jun 19, 2013·JPEN. Journal of Parenteral and Enteral Nutrition·Deepika NehraMark Puder
Dec 30, 2011·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Hulya SungurtekinBunyamin Kaptanoglu
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Jan 8, 2016·Current Opinion in Organ Transplantation·Sabrina E Sanchez, Meghan A Arnold
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Jun 23, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Hau D LeMark Puder
May 31, 2011·The Surgical Clinics of North America·Deepika NehraMark Puder

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