PMID: 9438815Jan 23, 1998Paper

Effects of intravenous lipoprostaglandin E1 on neurogenic intermittent claudication

Journal of Spinal Disorders
M MurakamiH Moriya

Abstract

Circulation disturbances in the cauda equina and nerve roots have been implicated in the genesis of neurogenic intermittent claudication (NIC) in patients with lumbar spinal stenosis (LSS). We report the clinical results of lipoprostaglandin E1 (lipo-PGE1) treatments in patients with NIC. Lipo-PGE1 was administered intravenously for 10 consecutive days to 40 patients, 31 of whom showed a response to the treatment. Of the clinical symptoms examined, walking ability and leg numbness were significantly improved with an average effective period of 2.5 months. However, patients with radicular pain and severely affected patients did not respond well. Nerve root circulation in eight patients who subsequently underwent surgery was measured with a laser Doppler flowmeter. We observed increased blood flow in seven of these eight patients, after the intraoperative administration of lipo-PGE1. Lipo-PGE1 produced symptomatic improvement for a limited period in the treatment of NIC associated with LSS. The drug appeared to exert its effects through an increase in the circulation of blood in the nerve roots and the cauda equina.

Citations

Oct 24, 2012·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Akira OndaShin-Ichi Konno
Apr 20, 2001·Progress in Neurobiology·J OrendácováN Katsube
Aug 9, 2003·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Katsuhiko NakaiNobuo Katsube
Jan 23, 2015·Pain Practice : the Official Journal of World Institute of Pain·Hiroyuki Yoshihara
Mar 27, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Shigeru KobayashiYoshihiko Suzuki
Jul 9, 2013·The Spine Journal : Official Journal of the North American Spine Society·D Scott KreinerUNKNOWN North American Spine Society
Dec 3, 2014·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·SuRak EoChiYeon Lim
Sep 2, 2016·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Yoshihito SakaiKen Watanabe
Dec 7, 2016·Regional Anesthesia and Pain Medicine·Eunjoo ChoiPyung Bok Lee
May 28, 2013·Yonsei Medical Journal·Seiji OhtoriUNKNOWN Chiba Low Back Pain Research Group

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