Abstract
Intravenous methylprednisolone (IVMP) may inhibit inflammatory cell recruitment to active MS lesions by effects on leukocyte or endothelial cell adhesion molecule expression. We investigated 15 MS patients in relapse receiving a 5-day course of IVMP (500 mg/day) and 15 normal subjects. Patients' blood samples were obtained pretreatment, at 6 and 24 hours after the first dose, and 48 hours after completion of therapy. Levels of L-selectin, leukocyte functional antigen 1 (LFA-1), Mac-1, and very late activation antigen 4 (VLA-4) expression were determined on alphabeta and gammadelta T cells and monocytes by dual-color immunofluorescent flow cytometry. Serum levels of soluble (s) L-selectin, sE-selectin, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured by ELISA. There was a marked decrease in the T-cell and monocyte counts at 6 hours after therapy, with recovery to baseline at 24 to 48 hours. Adhesion molecule expression was normal on circulating T cells and monocytes in active MS. IVMP resulted in significant changes in the percent adhesion molecule expression on monocytes: increased L-selectin expression at 24 hours, decreased Mac-1 expression at 6 hours, a...Continue Reading
References
Jan 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·P K PanegyresP C Blumbergs
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A StephensonV M Chapman
Jan 1, 1991·Neurology·J F KurtzkeM A Smith
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·S R HammondM G McCall
Jan 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·S HenleyA Tupper
Jul 1, 1974·The Journal of Clinical Investigation·W N SukiG Eknoyan
Jan 1, 1995·Annals of Neurology·J N WhitakerG R Cutter
Mar 1, 1994·The International Journal of Neuroscience·S Coren
Jul 1, 1993·The New England Journal of Medicine·M PackerM K Jolly
Jan 1, 1996·Arthritis and Rheumatism
Jan 1, 1996·Journal of Neuroimmunology·J J SeguraJ R Calvo
May 1, 1996·Journal of Neuroimmunology·A BlumJ V Weinstock
Citations
Oct 27, 2004·Journal of Neurology·Nina AirlaTerho Lehtimäki
Aug 5, 1998·International Journal of Clinical & Laboratory Research·A D CrockardS A Hawkins
May 11, 2005·Journal of the Neurological Sciences·Robert Zivadinov
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elliot M FrohmanOlaf Stüve
Dec 18, 2001·Brain Research. Brain Research Reviews·B MarchettiN Barden
Mar 10, 2001·Journal of Neuroimmunology·T MisuY Itoyama
Dec 14, 1999·Clinical and Experimental Immunology·N J GouldingC Pitzalis
Feb 17, 2006·Spine·Axel FinckhAlexander K L So
Dec 2, 2005·Clinical Nuclear Medicine·Phillip H KuoRahat Sadar
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Gordana ToncevGoran Samardzic
Sep 28, 1999·Current Opinion in Neurology·B C KieseierH P Hartung
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Nancy L KuntzUNKNOWN Network of US Pediatric Multiple Sclerosis Centers
Mar 8, 2005·Journal of Neuroimmunology·J GraberS Dhib-Jalbut
Oct 7, 2004·Journal of Neuroimmunology·L R SavilleG A Dekaban
Jul 21, 2004·Journal of the Neurological Sciences·Carlo PozzilliFrancesca Bagnato
Jul 28, 1999·Biochemical Pharmacology·F ButtgereitG R Burmester
Oct 14, 2000·Experimental Neurology·P J MabonG A Dekaban
Nov 6, 2004·Acta Neurologica Scandinavica·A BitschB Kitze
Sep 7, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M GelatiA Salmaggi
Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N N SpirinaA N Boyko