Effects of intravenous methylprednisolone therapy on leukocyte and soluble adhesion molecule expression in MS

Neurology
A G DrooganS A Hawkins

Abstract

Intravenous methylprednisolone (IVMP) may inhibit inflammatory cell recruitment to active MS lesions by effects on leukocyte or endothelial cell adhesion molecule expression. We investigated 15 MS patients in relapse receiving a 5-day course of IVMP (500 mg/day) and 15 normal subjects. Patients' blood samples were obtained pretreatment, at 6 and 24 hours after the first dose, and 48 hours after completion of therapy. Levels of L-selectin, leukocyte functional antigen 1 (LFA-1), Mac-1, and very late activation antigen 4 (VLA-4) expression were determined on alphabeta and gammadelta T cells and monocytes by dual-color immunofluorescent flow cytometry. Serum levels of soluble (s) L-selectin, sE-selectin, soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured by ELISA. There was a marked decrease in the T-cell and monocyte counts at 6 hours after therapy, with recovery to baseline at 24 to 48 hours. Adhesion molecule expression was normal on circulating T cells and monocytes in active MS. IVMP resulted in significant changes in the percent adhesion molecule expression on monocytes: increased L-selectin expression at 24 hours, decreased Mac-1 expression at 6 hours, a...Continue Reading

References

Jan 1, 1992·Journal of Neurology, Neurosurgery, and Psychiatry·P K PanegyresP C Blumbergs
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A StephensonV M Chapman
Jan 1, 1991·Neurology·J F KurtzkeM A Smith
Jan 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·S R HammondM G McCall
Jan 1, 1985·Journal of Neurology, Neurosurgery, and Psychiatry·S HenleyA Tupper
Jul 1, 1974·The Journal of Clinical Investigation·W N SukiG Eknoyan

❮ Previous
Next ❯

Citations

May 11, 2005·Journal of the Neurological Sciences·Robert Zivadinov
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Elliot M FrohmanOlaf Stüve
Jul 13, 2002·Clinical Chemistry and Laboratory Medicine : CCLM·Gordana ToncevGoran Samardzic
Sep 28, 1999·Current Opinion in Neurology·B C KieseierH P Hartung
Feb 19, 2010·Expert Opinion on Pharmacotherapy·Nancy L KuntzUNKNOWN Network of US Pediatric Multiple Sclerosis Centers
Jul 21, 2004·Journal of the Neurological Sciences·Carlo PozzilliFrancesca Bagnato
Sep 7, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·M GelatiA Salmaggi
Aug 28, 2020·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N N SpirinaA N Boyko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.