Effects of intravenous nitroglycerin on hemodynamics in neonates with refractory congestive heart failure or PFC

Acta Paediatrica Japonica; Overseas Edition
M Tamura, T Kawano

Abstract

(1) Continuous intravenous infusion (2-10 micrograms/kg/min) of nitroglycerin (TNG) was administered to 20 neonates consisting of 17 with refractory congestive heart failure and 3 with PFC (Persistent Fetal Circulation). (2) At doses of 2-4 micrograms/kg/min, there were no significant changes in heart rate or systemic blood pressure. (3) At doses of 2-4 micrograms/kg/min, the CVP was significantly reduced and urinary output increased. (4) Echocardiograms revealed a significant decrease in LVS at 4-5 micrograms/kg/min. In addition, the EF and cardiac output were significantly increased at 2-5 micrograms/kg/min. (5) The right ventricle systolic time interval (STI) was reduced significantly at 2 micrograms/kg/min. The left ventricle STI was not reduced below doses of 4 micrograms/kg/min. (6) In the dose range 2-5 micrograms/kg/min, TNG is an effective and safe vasodilator in the treatment of refractory congestive heart failure or PFC in neonates.

References

Aug 12, 1978·Lancet·P A CossumG W Boyd
Oct 1, 1978·American Heart Journal·J E Cottrell, H Turndorf
Jan 1, 1986·The American Review of Respiratory Disease·L R FrankelN J Lewiston
Jan 1, 1983·Intensive Care Medicine·C Blakeley, J Tinker

❮ Previous
Next ❯

Citations

Apr 1, 1992·Archives of Disease in Childhood·J R SkinnerE N Hey
Aug 24, 2002·Archives of Disease in Childhood. Fetal and Neonatal Edition·G P FrawleyP Loughnan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.