PMID: 3759552Aug 1, 1986Paper

Effects of intravenously infused Fluosol-DA 20% in rats

International Journal of Radiation Oncology, Biology, Physics
L WestC Wisdom

Abstract

Rats were injected with a fractionated 50 ml/kg dose of Fluosol-DA 20% with and without exposure to 100% oxygen. Animals were killed at 24, 43, 92, and 183 days post-treatment and samples taken for hematological, hepatic enzyme, histological, and perfluorochemical analyses. There were no significant differences in hemograms or hepatic enzyme findings between treatment and control groups. Differences in organ weights and histology were a result of perfluorochemical (PFC) accumulation in the tissues of treated animals. All changes were reversible. There were no effects from breathing high oxygen levels in either treatment or control animals.

References

Jun 1, 1975·Chemical & Pharmaceutical Bulletin·K YamanouchiK Yokoyama
Mar 2, 1984·Science·B A Teicher, C M Rose

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Citations

Jan 1, 1987·Comparative Biochemistry and Physiology. A, Comparative Physiology·K C Lowe
Aug 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C RoseB Teicher
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·E LartigauM Guichard
Jan 1, 1988·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A D Bollands, K C Lowe
Jan 1, 1989·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·K C LoweP D Raven
Mar 1, 1993·The Journal of Pharmacy and Pharmacology·P K BentleyK C Lowe
Jan 1, 1990·Critical Reviews in Oncology/hematology·C N Coleman, A T Turrisi
Jan 1, 1990·American Journal of Human Biology : the Official Journal of the Human Biology Council·S B GoingT W Boyden
Jan 1, 1988·Biomaterials, Artificial Cells, and Artificial Organs·S Rockwell
May 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M Guichard

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