Effects of intravitreal and intravenous administrations of dopamine on the standing potential and the light peak in the intact chicken eye

Current Eye Research
G Rudolf, N Wioland

Abstract

We studied the modifications of the standing potential (SP) of the eye and of the light peak (LP) after exposure to dopamine, a neurotransmitter released at light by the inner retina and known to affect electrical properties of the retinal pigment epithelium. Intravenous or intravitreal injections of dopamine (DA) were performed on intact chickens. "Choroidal" application (through an intravenous injection) induced a transient increase of the SP and the LP was preserved. On the other hand, "apical" applications of DA (through an intraocular injection) also increased the SP but considerably depressed the LP. These results are in agreement with the hypothesis that the light-induced release of dopamine from the neuroretina may be responsible for the LP generation in the intact chicken eye.

References

May 1, 1989·Documenta Ophthalmologica. Advances in Ophthalmology·G RudolfN Bonaventure
Oct 20, 1987·Brain Research·G C Brainard, W W Morgan
Oct 15, 1985·Documenta Ophthalmologica. Advances in Ophthalmology·N Wioland, N Bonaventure
Jan 1, 1984·Experimental Eye Research·S W Koh, G J Chader
Oct 1, 1982·The Journal of Physiology·E R Griff, R H Steinberg
Oct 1, 1982·The Journal of Physiology·R A Linsenmeier, R H Steinberg

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Citations

Mar 1, 1995·The British Journal of Ophthalmology·C Williams, D Papakostopoulos
Feb 18, 2016·Neural Plasticity·Thomas SchwitzerVincent Laprevote
Feb 14, 2006·Progress in Retinal and Eye Research·Geoffrey B Arden, Paul A Constable

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