Effects of intravitreal injection of ranibizumab on choroidal structure and blood flow in eyes with diabetic macular edema

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Masahiro OkamotoNahoko Ogata

Abstract

To determine the effects of an intravitreal injection of ranibizumab (IVR) on the choroidal structure and blood flow in eyes with diabetic macular edema (DME). Twenty-eight consecutive patients with DME who received an IVR and 20 non-diabetic, age-matched controls were followed for 1 month. The eyes with DME were divided into those with prior panretinal photocoagulation (PRP, n = 16) and those without prior PRP (no-PRP, n = 12). The enhanced depth imaging optical coherence tomography (EDI-OCT) scans and Niblack's image binarization were performed to determine the choroidal structure. The choroidal blood flow was determined by laser speckle flowgraphy. The subfoveal choroidal thickness at the baseline was significantly thicker in the no-PRP group than in the PRP-treated group. After IVR, the best-corrected visual acuity (BCVA) and central retinal thickness in eyes with DME were significantly improved compared to the baseline values. There were significant differences in the choroidal thickness, total choroidal area, and choroidal vascularity index between the groups after IVR. Choroidal vascular index and choroidal blood flow were significantly reduced only in the no-PRP group and not in the PRP-treated group. In addition, the c...Continue Reading

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Citations

Apr 14, 2019·The British Journal of Ophthalmology·Anna Sophie Mursch-EdlmayrMatthias Bolz
Apr 17, 2020·Investigative Ophthalmology & Visual Science·Zhouyue LiXiao Yang
Jun 10, 2019·The British Journal of Ophthalmology·Satoru KaseManabu Kase
Aug 22, 2020·Translational Vision Science & Technology·Giacomo CalzettiLeopold Schmetterer
May 29, 2020·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Mustafa AksoyImren Akkoyun
Mar 20, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Hiroaki EndoManabu Kase
Feb 1, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Satoru KaseManabu Kase
Jan 31, 2021·The British Journal of Ophthalmology·Bjorn Kaijun BetzlerRupesh Agrawal
Jan 26, 2021·Journal of Diabetes Research·Corina-Iuliana SuciuSimona-Delia Nicoara
Apr 24, 2021·World Journal of Diabetes·Ştefan Ţălu, Simona Delia Nicoara

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