PMID: 3746158Aug 1, 1986Paper

Effects of iodide and thyroxine on iodine-deficient mouse thyroid: a morphological and functional study

The Journal of Endocrinology
M C ManyC Beckers

Abstract

The effects of iodide and thyroxine (T4) on female mice fed a low iodine diet (LID) for 8 weeks were analysed by morphological, stereological and biochemical methods. Iodide was given at a dose of 10 micrograms/day (HID) or 1 microgram/day (MID), either alone or together with daily injections of 1 microgram T4 for 8 or 40 days. With HID, the thyroid weight and the numbers of follicles and cells remained higher than in controls, although cell necrosis occurred. Colloid volume increased and iodine was stored within the gland: a colloid goitre with non-functioning follicles was produced. With MID, the glands resumed an almost normal appearance. With T4 and LID, progressive normalization occurred, but after 40 days thyroid weight and numbers of follicles and cells remained higher than in controls. Glandular iodine content slowly increased and reached control value. The proportions of 125I-labelled tri-iodothyronine (T3) and T4 in thyroglobulin were reduced. With T4 and HID, the glands resumed a normal appearance. Neither necrosis nor folliculoneogenesis was noted. The proportions of 125I-labelled T3 and T4 in thyroglobulin were reduced, but T3 and T4 serum levels were higher than with HID. With T4 and MID, a normal state was obtain...Continue Reading

Citations

Jul 1, 1987·Klinische Wochenschrift·G Hintze, J Köbberling
Apr 14, 2011·Langenbeck's Archives of Surgery·Ralf Paschke
Jan 1, 1988·Tissue & Cell·P P Krupp, K P Lee
Mar 16, 2000·Thyroid : Official Journal of the American Thyroid Association·R B Burikhanov, S Matsuzaki
Sep 29, 2007·Thyroid : Official Journal of the American Thyroid Association·George Carayanniotis
Oct 1, 2013·Thyroid : Official Journal of the American Thyroid Association·Ides M ColinAnne-Catherine Gérard
Jan 26, 2013·Endocrine Reviews·Ides M ColinAnne-Catherine Gérard
Apr 23, 2011·Annales d'endocrinologie·R Paschke
Dec 24, 2004·Endocrine Reviews·Knut KrohnRalf Paschke

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