Effects of Iodized Salt and Iodine Supplements on Prenatal and Postnatal Growth: A Systematic Review

Advances in Nutrition
Jessica FarebrotherMichael B Zimmermann

Abstract

Hypothyroidism due to iodine deficiency can impair physical development, most visibly in the marked stunting of myxedematous cretinism caused by severe in utero iodine deficiency. Whether iodine repletion improves growth in noncretinous children is uncertain. Therefore, the aim of our systematic review was to assess the effects of iodine fortification or supplementation on prenatal and postnatal growth outcomes in noncretinous children. Following Cochrane methods and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) reporting guidelines, we searched 10 databases including 2 Chinese databases (latest search February 2017). We included randomized and nonrandomized controlled trials (RCTs; non-RCTs), controlled before-after (CBA) studies, and interrupted time-series studies in pregnant women and children (≤18 y), which compared the effects of iodine (any form, dose, regimen) to placebo, noniodized salt, or no intervention on prenatal and postnatal growth outcomes. We calculated mean differences with 95% CIs, performed random-effects meta-analyses, and assessed the quality of evidence with the use of GRADE (Grading of Recommendations Assessment, Development and Evaluation). We included 18 studies (13 RCTs,...Continue Reading

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Citations

Jan 17, 2019·Thyroid : Official Journal of the American Thyroid Association·Jessica FarebrotherMaria Andersson
Jan 16, 2020·Journal of Clinical Medicine·Inés VelascoEduardo García-Fuentes
Feb 16, 2021·Journal of Clinical Epidemiology·Sarah S WernerLukas Schwingshackl
Nov 14, 2020·European Journal of Clinical Nutrition·Jessica FarebrotherAngela C Flynn
Jul 25, 2021·International Journal of Environmental Research and Public Health·Fuad I AbbagNabil J Awadalla
Oct 3, 2021·Archives of Gynecology and Obstetrics·Yaniv S OvadiaSimon Shenhav
Nov 19, 2021·Endocrine Reviews·Maria Andersson, Christian P Braegger

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