Effects of ion source operating parameters on direct analysis in real time of 18 active components from traditional Chinese medicine

Journal of Pharmaceutical and Biomedical Analysis
Lu WangHaibin Qu

Abstract

Direct analysis in real time mass spectrometry (DART-MS) provides a new analytical method for traditional Chinese medicine (TCM). The present study investigated the effects of key ion source operating parameters on DART-MS analysis of various TCM active components. A total of 18 active components, including phenylpropanoids, alkaloids, saponins, flavones, volatile oils, and glycosides, were examined. For each substance, the peak area and signal-to-noise of its characteristic ions under different reagent gases and heater temperatures were compared. Based on the comparison, the relationships among chemical structures, ion source parameters and instrument responses were revealed. Finally, some suggestions about choosing reagent gas and heater temperature were proposed for types of TCM active substance, which offered a reference for the application of DART-MS on TCM analysis.

References

Sep 16, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·L K AckermanT H Begley
Apr 19, 2011·Analytical Chemistry·Glenn A HarrisFacundo M Fernández
Jan 10, 2012·Rapid Communications in Mass Spectrometry : RCM·Daudi S Saang'onyo, Darrin L Smith
Dec 19, 2013·Journal of the American Society for Mass Spectrometry·Lu WangHaibin Qu
May 2, 2015·Journal of the American Society for Mass Spectrometry·Liya ZhangYiyang Dong

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