PMID: 9159508Apr 25, 1997Paper

Effects of iontophoretically applied serotonin on three classes of physiologically characterized putative pain modulating neurons in the rostral ventromedial medulla of lightly anesthetized rats

Neuroscience Letters
S M Roychowdhury, Mary M Heinricher

Abstract

The importance of the rostral ventromedial medulla (RVM) in nociceptive modulation is well documented, and several lines of evidence point to a role for serotonin (5HT) in regulating the activity of pain modulating neurons in this region. The aim of the present study was to examine the effect of iontophoretically applied 5HT upon the firing of three physiologically defined classes of RVM neurons with distinct roles in pain modulation. The predominant effect across all classes was a facilitation of ongoing or evoked activity. A minority of cells within each class were inhibited by 5HT itself, but agonists at 5HT1 receptor types inhibited the majority of cells tested. The results thus indicate that the behavioral effects of manipulating 5HT within the RVM cannot be attributed to a selective influence on a particular cell class.

References

Feb 19, 1985·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·H L Fields, M M Heinricher
Jun 1, 1988·British Journal of Pharmacology·M DavieM H Roberts
Jun 1, 1988·British Journal of Pharmacology·M DaviesM H Roberts
Nov 21, 1983·Brain Research·M W Wessendorf, E G Anderson

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Citations

Nov 3, 2009·Okajimas Folia Anatomica Japonica·Michiko Nakatsuka, Yasutomo Iwai
May 30, 2006·Brain Research·Valerie A SmithMichael R Brandt
Sep 14, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A YamamotováR Šlamberová
Sep 25, 2020·Cellular and Molecular Neurobiology·Grace C Rossi, Richard J Bodnar

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