Effects of iprindole on responses of single cortical and caudate neurones to monoamines and acetylcholine.

British Journal of Pharmacology
P BevanE Szabadi

Abstract

1 The technique of microelectrophoresis was used to study the effects of iprindole on single neurones in the cerebral cortex and caudate nucleus of the rat. 2 Iprindole, when applied for a brief period, did not affect the firing rate of the vast majority of neurones tested. 3 Both potentiation and antagonism of neuronal responses to noradrenaline, dopamine, and 5-hydroxytryptamine could be observed after a brief application of iprindole. Potentiation and antagonism often occurred after the same application of iprindole, antagonism always preceding potentiation. 4 Responses to acetylcholine were affected by iprindole similarly: both potentiation and antagonism of the responses could be observed. 5 Responses to glutamate were not affected by iprindole. 6 It is concluded that the potentiation of responses to monoamines by iprindole cannot be explained on the basis of uptake blockade; this potentiation may be due to the blockade of masked receptors on the post-synaptic cell. 7. It is suggested that the common pharmacological action of the tricyclic antidepressants may be the ability to block both monoamine and acetylcholine receptors in the brain.

References

Jan 1, 1975·British Journal of Pharmacology·P BevanE Szabadi
Jul 15, 1974·Biochemical Pharmacology·L L Iversen
Jan 1, 1974·Psychopharmacologia·B N Rosloff, J M Davis
Sep 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·K RickelsJ H Simon
Jan 1, 1970·International Review of Neurobiology·J M Davis
Nov 1, 1965·The American Journal of Psychiatry·J J Schildkraut
Sep 1, 1969·European Journal of Pharmacology·S B Ross, A L Renyi
Dec 1, 1967·European Journal of Pharmacology·S B Ross, A L Renyi

❮ Previous
Next ❯

Citations

Aug 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·S A Doggrell, J B Waldron
Jan 1, 1980·Journal of Neural Transmission·J M Cott, S O Ogren
Dec 1, 1976·European Journal of Pharmacology·M Weinstock, D Cohen
Aug 1, 1978·Neuropharmacology·P BevanE Szabadi
Jan 1, 1979·Neuroscience·P C Emson, O Lindvall
May 1, 1976·British Journal of Pharmacology·P BevanE Szabadi
Mar 1, 1979·British Journal of Pharmacology·R S Jones, M H Roberts
Mar 1, 1977·British Journal of Pharmacology·K G GreinerJ R Wood
Jun 27, 2019·Organic & Biomolecular Chemistry·Gaurav R GuptaAnant R Kapdi
Feb 1, 1979·The Journal of Pharmacy and Pharmacology·R S Jones, M H Roberts

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.