Effects of iron-chelators on ion-channels and HIF-1alpha in the carotid body

Respiratory Physiology & Neurobiology
Arijit RoyS Lahiri

Abstract

Acute hypoxia instantaneously increases the chemosensory discharge from the carotid body, increasing ventilation mostly by inhibiting the oxygen sensitive ion channels and exciting the mitochondrial functions in the glomus cells. On the other hand, Fe2+-chelation mimics hypoxia by inhibiting the prolyl hydroxylases and the degradation of HIF-1alpha in non-excitable cells. Whether Fe2+-chelation can inhibit the ion channels giving rise to the sensory responses in excitable cells was the question. We characterized the responses to Fe2+-chelators on excitable glomus cells of the rat, and found that they instantaneously blocked the ion-channels, exciting the chemosensory discharge, and later causing a gradual accumulation of HIF-1alpha. Although initiated by the same stimuli, the two effects (on ion channels and cytosolic HIF-1alpha) possibly occurred by two different mechanisms.

References

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Citations

Aug 3, 2005·High Altitude Medicine & Biology·David F WilsonSukhamay Lahiri
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helmut Acker
Sep 3, 2005·Progress in Biophysics and Molecular Biology·S LahiriN R Prabhakar
Jul 22, 2005·Histochemistry and Cell Biology·Santhosh M BabySukhamay Lahiri
Nov 14, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Alexander BalbirMachiko Shirahata
May 4, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Arijit RoySukhamay Lahiri
Dec 18, 2004·Science·Toshinori Hoshi, Sukhamay Lahiri

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