PMID: 6976117Dec 1, 1981Paper

Effects of iron deficiency anemia on delayed cutaneous hypersensitivity in mice

The American Journal of Clinical Nutrition
S KuvibidilaR M Suskind

Abstract

In the present study, the effect of iron-deficiency anemia on delayed cutaneous hypersensitivity was measured using weanling C57BL/6 female mice which were fed either an ad libitum control diet supplemented with 25 to 30 mg Fe/kg diet (FePO4), an iron-deficient test diet (5 to 6 mg Fe/kg diet), or pairfed control diet (25 to 30 mg Fe/kg diet). When skin sensitizing agent (dinitrofluorobenzene) was applied to these animals and skin responses were measured 3 to 5 days later, anemic mice showed a significantly decreased inflammatory skin response than either control or pairfed mice. Five days after sensitization, the animals were challenged with dinitrofluorobenzene painted on the right ear and an equal dose of only the solvent on the left ear followed by 125I-deoxyuridine injected intraperitoneally. The ratio of either total or DNA associated radioactivity incorporated into the right over the left ears was significantly lower in anemic mice than either control or pairfed mice. A single dose of Imferon injected 24 h before the recall dose of dinitrofluorobenzene restored the ratio of 125I-dUR incorporated in anemic mice without having any significant effect on either the control or pairfed groups. The results suggest that iron is ...Continue Reading

Citations

Jan 1, 1987·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·L Q Tian, Q H Zhu
May 1, 1982·Indian Journal of Pediatrics·B S BaligaR M Suskind
Jan 1, 1985·Free Radical Research Communications·S BrailsfordD R Blake
Feb 1, 1983·European Journal of Clinical Microbiology·B S van Asbeck, J Verhoef
Sep 30, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Bobby J Cherayil
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·M J Farthing
Sep 1, 1986·The Proceedings of the Nutrition Society·J H Brock, T Mainou-Fowler
Dec 1, 1994·The British Journal of Nutrition·F O Omara, B R Blakley
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Dec 1, 1983·Immunology Today·J H Brock, T Mainou-Fowler
Apr 1, 1989·Baillière's Clinical Haematology·T E Peto, C Hershko

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