Effects of iron-EDTA on uroporphyrinogen oxidation by liver microsomes

FEBS Letters
J M JacobsJ F Sinclair

Abstract

Uroporphyrinogen oxidation by hepatic microsomes from chick embryos or mice pretreated with methylcholanthrene was increased by addition of iron-EDTA. This increase was partially prevented by catalase, mannitol, ketoconazole and piperonyl butoxide, whereas only ketoconazole and piperonyl butoxide inhibited the oxidation in the presence and absence of iron-EDTA. These data suggest that the oxidations of uroporphyrinogen in the presence and absence of added iron occur by different mechanisms.

References

Aug 15, 1988·Analytical Biochemistry·J K GradyD C Harris
May 16, 1988·Biochemical and Biophysical Research Communications·J S Woods
Jul 15, 1988·The Biochemical Journal·A J UrquhartJ A Sinclair
Jan 1, 1988·European Journal of Nuclear Medicine·E J ter BorgC J Thijn
Nov 1, 1968·Biochemical Pharmacology·M W Anders
Apr 15, 1981·The Biochemical Journal·H L BonkowskyJ S Pomeroy

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Citations

Jan 1, 1990·Journal of Biochemical Toxicology·J M JacobsN J Jacobs
Apr 1, 1995·Journal of Bioenergetics and Biomembranes·G H Elder, A G Roberts
Feb 11, 1999·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·N GormanP R Sinclair
Sep 15, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nadia GormanPeter R Sinclair
Sep 1, 1990·Journal of Gastroenterology and Hepatology·J M RankJ R Bloomer
May 1, 1992·Archives of Biochemistry and Biophysics·R W LambrechtJ F Sinclair
Sep 1, 1990·Archives of Biochemistry and Biophysics·S K Mukerji, N R Pimstone

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