PMID: 2491639Jan 1, 1989Paper

Effects of irradiation on diabetes in the BB/Wor rat

Autoimmunity
E S HandlerA A Rossini

Abstract

Lymphoid irradiation is known to prevent spontaneous autoimmune diabetes in susceptible BB rats. The present studies investigated further the effects of radiation in diabetes prone (DP) and resistant (DR) BB/Wor rats, and histocompatible Yoshida (YOS) rats. Single doses of total body gamma irradiation (125-600 rads) induced diabetes within 22-44 days in 20 of 102 (20%) 30 day old DR rats, less than 1% of which develop the disease. Radiation was also associated with (1) a reduction in the ratio of W3/25+ to OX8+ peripheral blood lymphocytes within 2 weeks, and (2) a decreased percentage of lymph node cells expressing the RT6.1 surface alloantigen 3-4 weeks after treatment. Similar doses of irradiation did not alter the frequency or age at onset of diabetes in DP rats, and did not induce diabetes in YOS rats. When a single dose of 250 or 500 rads of gamma irradiation was followed by injection of mitogen activated spleen cells from acutely diabetic rats to adoptively transfer diabetes, 16 of 19 (84%) DR and 8 of 14 (57%) YOS rats became diabetic. Long term exposure to ultraviolet irradiation (UVB) did not alter the frequency or age at onset of diabetes in either DP or DR rats. We conclude that there may exist a population of regul...Continue Reading

References

Feb 1, 1985·Diabetes·U OschilewskiH Kolb
Jul 1, 1988·Cellular Immunology·C F MojcikI Goldschneider
Jul 1, 1987·Diabetes/metabolism Reviews·J P MordesA A Rossini
Aug 1, 1987·The Journal of Experimental Medicine·D L GreinerA A Rossini
May 1, 1985·AJR. American Journal of Roentgenology·R G Evens, F A Mettler
Oct 1, 1985·The Journal of Clinical Investigation·E S HandlerA A Rossini
Jan 1, 1983·Lancet·A LaupacisP Thibert
Aug 1, 1984·Immunological Reviews·M L Kripke
Jul 1, 1984·The Journal of Clinical Investigation·A A RossiniJ P Mordes
May 13, 1983·Science·S KoevaryR M Williams
Oct 1, 1981·Diabetes·R JacksonG S Eisenbarth

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