PMID: 1199946Dec 11, 1975Paper

Effects of ischemia and coronary reperfusion on myocardial digoxin uptake

The American Journal of Cardiology
G A BellerW B Hood

Abstract

The effects of coronary reperfusion on the uptake of digoxin by ischemic myocardium were studied in 17 open chest dogs undergoing anterior wall infarction produced by snaring confluent branches of the left coronary arterial system. Epicardial electrograms delineated ischemic, border and nonischemic zones. The hearts were reperfused by snare release after 1, 2 and 6 hours of occlusion. After 15 minutes of reperfusion, 1.0 mg of tritiated digoxin (3H-digoxin) was given intravenously, and 2 hours later the hearts were excised and endocardial and epicardial samples from each zone were analyzed for 3H-digoxin concentration. In another group of eight dogs regional myocardial blood flow was assessed utilizing 15 mu of radio-labeled microspheres administered during occlusion and reperfusion. In five dogs with 1 hour of coronary occlusion and subsequent reperfusion, 3H-digoxin uptake was comparable in endocardial and epicardial layers of all three zones. In six dogs undergoing reperfusion after 2 hours of occlusion, mean 3H-digoxin concentration was significantly (P less than 0.001) reduced from the mean nonischemic concentration, by 54 percent in endocardial and 35 percent in epicardial layers of the ischemic zone. Border zone endocard...Continue Reading

Citations

Aug 1, 1979·European Journal of Pharmacology·D D Ku, B R Lucchesi
Apr 23, 1982·European Journal of Pharmacology·H S Karagueuzian, B G Katzung
Jul 1, 1983·Journal of the American College of Cardiology·Y IesakaJ W Lister
Feb 1, 1976·The Journal of Clinical Investigation·G A BellerT W Smith

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