Effects of ischemia on cerebral arteriolar dilation to arterial hypoxia in piglets

Stroke; a Journal of Cerebral Circulation
Ferenc BariD W Busija

Abstract

Arterial hypoxia mediates cerebral arteriolar dilation primarily via mechanisms involving activation of ATP-sensitive K+ channels (K[ATP]), which we have shown to be sensitive to ischemic stress. In this study, we determined whether ischemia/reperfusion alters cerebral arteriolar responses to arterial hypoxia in anesthetized piglets. Since adenosine plays an important role in cerebrovascular responses to hypoxia, we also determined whether adenosine-induced arteriolar dilation is affected by ischemic stress. We tested the hypothesis that reductions in cerebral arteriolar dilator responses after ischemia would be proportional to the contribution of K(ATP) to hypoxia and adenosine. Pial arteriolar diameters were measured using a cranial window and intravital microscopy. We examined arteriolar responses to arterial hypoxia (inhalation of 8.5% and 7.5% O2), to topical adenosine (10[-5] and 10[-4] mol/L) and to arterial hypercapnia (inhalation of 5% and 10% CO2 in air) before and after 10 minutes of global ischemia. Ischemia was achieved by increasing intracranial pressure. Arterial hypercapnia was used as a positive control for the effectiveness of the ischemic insult. In addition, we evaluated cerebral arteriolar responses to 10(-...Continue Reading

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Citations

May 3, 2002·Clinical and Experimental Pharmacology & Physiology·Joseph E Brayden
Oct 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F M Faraci, C G Sobey
Jun 17, 2008·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Eun A KoWon Sun Park
Dec 20, 2012·Stroke Research and Treatment·Marcel A KampDaniel Hänggi
Nov 6, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anuska V AndjelkovicRichard F Keep
Jul 17, 2007·Progress in Cardiovascular Diseases·Antonio Franco Folino
Jan 4, 2006·Brain Research·Ferenc BariFerenc Domoki
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Sep 17, 2002·The Journal of Physiology·Arlin B BloodGordon G Power
Apr 4, 2007·Journal of Neurotrauma·Ji-Yao LiTakehiko Yanagihara
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Sep 14, 1999·The American Journal of Physiology·F DomokiD W Busija
Dec 18, 2002·Experimental Biology and Medicine·William M Armstead

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