Effects of isoflurane-induced and prostaglandin E(1)-induced hypotension on cytokine responses to oral and maxillofacial surgery

Journal of Clinical Anesthesia
Takuya MiyawakiMasahiko Shimada

Abstract

To evaluate the effect of induced hypotension with isoflurane or prostaglandin E(1) (PGE(1)) on cytokine responses to surgery. Prospective, randomized study. University hospital. 24 ASA physical status I and II patients undergoing elective oral and maxillofacial surgery. Patients were randomly allocated to three groups be anesthetized in the normotension (Control group), isoflurane-induced hypotension (Isoflurane-H group), and PGE(1)-induced hypotension (PGE(1)-H group). Mean arterial pressure during hypotension was maintained at approximately 80% of baseline values. Blood samples were taken before induction of anesthesia and during and after hypotension. Plasma tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-10 (IL-10) levels were measured using enzyme-linked immunosorbent assay. There were no differences in TNF-alpha or IL-10 levels among the groups. However, the elevation of the plasma IL-6 level in the PGE(1)-H group was found during hypotension, compared with the control group (p < 0.05). PGE(1)-induced hypotension has an effect on IL-6 response to oral and maxillofacial surgery.

References

Sep 1, 1989·Anesthesia and Analgesia·M R LessardP H Denault
Jun 1, 1994·Arthritis and Rheumatism·K N GoldJ J Goronzy
May 1, 1994·Acta Anaesthesiologica Scandinavica·I SchindlerT Kimla
Mar 1, 1994·British Journal of Anaesthesia·T A CrozierD Kettler
Jan 1, 1997·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·T KawamuraK Inada
Mar 21, 1998·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·T MiyawakiM Shimada
May 29, 1998·Journal of Clinical Anesthesia·M KatoY Hashimoto

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